Linked Life Data

8964039

Source:http://linkedlifedata.com/resource/pubmed/id/8964039

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1996-12-24
pubmed:abstractText
One of the roles of astrocytes in the maintenance of perineuronal ionic balance during intense neuronal activity occurring after injection of convulsant agents like soman. Soman is an irreversible cholinesterase inhibitor and induces brain damage with early swelling of astrocytic perivascular processes. Mature astrocytes are easily characterized on freeze-fracture replicas owing to the presence of regular geometric aggregates of intramembranous particles: the 'orthogonal arrays' (OAs). In primary cultures of astrocytes OA distribution is homogeneous throughout the plasma membrane. A present hypothesis (see review in Risau and Wolburg, 1990) considers that these OAs are associated with channels controlling potassium ion concentration in the cerebral parenchyma. We have investigated the effects of extracellular concentrations of K+ ions identical to those observed during neuronal activity on primary cultures of astrocytes and effects induced by soman. High concentrations of K+ ions (60 mM) as well as soman exerted direct effects on astrocytic plasma membranes: K+ ion influx within astrocytes induces a partial disaggregation of OAs and more acutely than soman. Neither K+ ions nor soman induce swelling of astrocytic end-feet.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1122-9497
pubmed:author
pubmed:issnType
Print
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
151-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Compared effects of extracellular K+ ions and soman, a neurotoxic, on cerebral astrocyte morphology. An in vitro study.
pubmed:affiliation
Laboratory of Cytology, CNRS URA 1488, Paris VI University, France.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't