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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1997-3-12
|
| pubmed:abstractText |
The genotypes of L-myc and GSTM1 genes were studied in normal lung tissues of 98 non-small cell lung carcinoma (NSCLC) patients from Hong Kong using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) techniques. Results showed a statistical difference in L-myc genotypes between Chinese and African Americans (P = 0.02). A significant deficit in heterozygotes resulting in the departure from Hardy-Weinberg equilibrium in lung cancer female patients was detected (0.01 < P < 0.02). There were significant differences in survival times in patients having L-L and S-S genotypes, with shorter survival times in the patients with L-L genotypes (0.01 < P < 0.05). Data on age, size of tumor, histological types, and lymph node metastasis showed no significant association with L-myc genotype. The survival time in the GSTM1-negative (null gene) group was significantly different from the GSTM1 positive group between 16 and 24 months after operation (0.01 < P < 0.05). There was no significant difference in the distribution of GSTM1 genotypes between Chinese and Caucasian Americans.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Probes,
http://linkedlifedata.com/resource/pubmed/chemical/Glutathione Transferase,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0169-5002
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
15
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
355-66
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8959680-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:8959680-China,
pubmed-meshheading:8959680-DNA, Neoplasm,
pubmed-meshheading:8959680-DNA Probes,
pubmed-meshheading:8959680-Female,
pubmed-meshheading:8959680-Genes, myc,
pubmed-meshheading:8959680-Genotype,
pubmed-meshheading:8959680-Glutathione Transferase,
pubmed-meshheading:8959680-Humans,
pubmed-meshheading:8959680-Isoenzymes,
pubmed-meshheading:8959680-Lung Neoplasms,
pubmed-meshheading:8959680-Male,
pubmed-meshheading:8959680-Middle Aged,
pubmed-meshheading:8959680-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:8959680-Questionnaires,
pubmed-meshheading:8959680-Risk Factors,
pubmed-meshheading:8959680-Sex Factors,
pubmed-meshheading:8959680-Survival Rate,
pubmed-meshheading:8959680-Tumor Markers, Biological
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Analysis of L-myc and GSTM1 genotypes in Chinese non-small cell lung carcinoma patients.
|
| pubmed:affiliation |
Department of Biology, Hong Kong University of Science and Technology, Kowloon, Hong Kong.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|