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rdf:type |
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|
lifeskim:mentions |
|
|
pubmed:issue |
2
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|
pubmed:dateCreated |
1997-1-22
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|
pubmed:abstractText |
Heat shock factor-1 (HSF-1), the transcriptional activator of heat shock genes has recently been shown to play a role in the repression of acute phase genes. We have further explored the role of HSF-1 in inflammatory processes in human monocytes. HSF-1 was activated in these cells by a wide range of classes of non-steroidal antiinflammatory drugs (NSAIDs) while being strongly repressed by pro-inflammatory stimuli. The experiments indicate reciprocal regulation of the acute phase and heat shock responses and suggest a novel target for the NSAID family of drugs.
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pubmed:grant |
|
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Dec
|
|
pubmed:issn |
0006-291X
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
13
|
|
pubmed:volume |
229
|
|
pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
479-84
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|
pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:8954923-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:8954923-Cell Line,
pubmed-meshheading:8954923-Cyclooxygenase Inhibitors,
pubmed-meshheading:8954923-DNA-Binding Proteins,
pubmed-meshheading:8954923-Heat-Shock Proteins,
pubmed-meshheading:8954923-Humans,
pubmed-meshheading:8954923-Hydroxyeicosatetraenoic Acids,
pubmed-meshheading:8954923-Inflammation Mediators,
pubmed-meshheading:8954923-Monocytes,
pubmed-meshheading:8954923-Transcription Factors
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|
pubmed:year |
1996
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|
pubmed:articleTitle |
Reciprocal effects of pro-inflammatory stimuli and anti-inflammatory drugs on the activity of heat shock factor-1 in human monocytes.
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|
pubmed:affiliation |
Dana Farber Cancer Institute, Boston, Massachusetts, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|
