Linked Life Data

8953423

Source:http://linkedlifedata.com/resource/pubmed/id/8953423

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pubmed-article:8953423pubmed:abstractTextThe marshland plant Cyperus articulatus (Cyperaceae) is commonly used in traditional medicine in Africa and Latin America to treat a wide variety of human diseases ranging from headache to epilepsy. We tested the hypothesis that the purported anti-epileptic effect of this plant might be due to a functional inhibition of excitatory amino acid receptors. One or several component(s) contained in the extracts inhibited the binding of [3H]CGP39653 to the NMDA recognition site and of [3H]glycine to the strychnine-insensitive glycine site of the NMDA receptor complex from rat neocortex. Water extracts from rhizomes of Cyperus articulatus dose-dependently reduced spontaneous epileptiform discharges and NMDA-induced depolarizations in the rat cortical wedge preparation at concentrations at which AMPA-induced depolarizations were not affected. We conclude that the purported beneficial effects of Cyperus articulatus might at least partially be due to inhibition of NMDA-mediated neurotransmission.lld:pubmed
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pubmed-article:8953423pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:8953423pubmed:articleTitleExtracts from rhizomes of Cyperus articulatus (Cyperaceae) displace [3H]CGP39653 and [3H]glycine binding from cortical membranes and selectively inhibit NMDA receptor-mediated neurotransmission.lld:pubmed
pubmed-article:8953423pubmed:affiliationSandoz Research Institute Berne Ltd., Switzerland.lld:pubmed
pubmed-article:8953423pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:8953423pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed