rdf:type |
|
lifeskim:mentions |
umls-concept:C0001613,
umls-concept:C0007776,
umls-concept:C0022655,
umls-concept:C0025255,
umls-concept:C0027793,
umls-concept:C0079883,
umls-concept:C0949790,
umls-concept:C0950025,
umls-concept:C0950026,
umls-concept:C1148574,
umls-concept:C1555707,
umls-concept:C1705851,
umls-concept:C2752151,
umls-concept:C2828366
|
pubmed:issue |
2-3
|
pubmed:dateCreated |
1997-3-10
|
pubmed:abstractText |
The marshland plant Cyperus articulatus (Cyperaceae) is commonly used in traditional medicine in Africa and Latin America to treat a wide variety of human diseases ranging from headache to epilepsy. We tested the hypothesis that the purported anti-epileptic effect of this plant might be due to a functional inhibition of excitatory amino acid receptors. One or several component(s) contained in the extracts inhibited the binding of [3H]CGP39653 to the NMDA recognition site and of [3H]glycine to the strychnine-insensitive glycine site of the NMDA receptor complex from rat neocortex. Water extracts from rhizomes of Cyperus articulatus dose-dependently reduced spontaneous epileptiform discharges and NMDA-induced depolarizations in the rat cortical wedge preparation at concentrations at which AMPA-induced depolarizations were not affected. We conclude that the purported beneficial effects of Cyperus articulatus might at least partially be due to inhibition of NMDA-mediated neurotransmission.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2-Amino-5-phosphonovalerate,
http://linkedlifedata.com/resource/pubmed/chemical/Anticonvulsants,
http://linkedlifedata.com/resource/pubmed/chemical/CGP 39653,
http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Glycine,
http://linkedlifedata.com/resource/pubmed/chemical/Piperazines,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Extracts,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, N-Methyl-D-Aspartate,
http://linkedlifedata.com/resource/pubmed/chemical/SDZ EAA 494,
http://linkedlifedata.com/resource/pubmed/chemical/Tritium
|
pubmed:status |
MEDLINE
|
pubmed:month |
Nov
|
pubmed:issn |
0378-8741
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
54
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
103-11
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:8953423-2-Amino-5-phosphonovalerate,
pubmed-meshheading:8953423-Animals,
pubmed-meshheading:8953423-Anticonvulsants,
pubmed-meshheading:8953423-Binding, Competitive,
pubmed-meshheading:8953423-Cerebral Cortex,
pubmed-meshheading:8953423-Excitatory Amino Acid Antagonists,
pubmed-meshheading:8953423-Glycine,
pubmed-meshheading:8953423-Male,
pubmed-meshheading:8953423-Membranes,
pubmed-meshheading:8953423-Piperazines,
pubmed-meshheading:8953423-Plant Extracts,
pubmed-meshheading:8953423-Plants, Medicinal,
pubmed-meshheading:8953423-Rats,
pubmed-meshheading:8953423-Rats, Sprague-Dawley,
pubmed-meshheading:8953423-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:8953423-Synaptic Transmission,
pubmed-meshheading:8953423-Tritium
|
pubmed:year |
1996
|
pubmed:articleTitle |
Extracts from rhizomes of Cyperus articulatus (Cyperaceae) displace [3H]CGP39653 and [3H]glycine binding from cortical membranes and selectively inhibit NMDA receptor-mediated neurotransmission.
|
pubmed:affiliation |
Sandoz Research Institute Berne Ltd., Switzerland.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|