|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5295
|
|
pubmed:dateCreated |
1997-1-9
|
|
pubmed:abstractText |
Cyclic guanosine 3',5'-monophosphate (cGMP)-dependent protein kinases (cGKs) mediate cellular signaling induced by nitric oxide and cGMP. Mice deficient in the type II cGK were resistant to Escherichia coli STa, an enterotoxin that stimulates cGMP accumulation and intestinal fluid secretion. The cGKII-deficient mice also developed dwarfism that was caused by a severe defect in endochondral ossification at the growth plates. These results indicate that cGKII plays a central role in diverse physiological processes.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0036-8075
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
20
|
|
pubmed:volume |
274
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2082-6
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:8953039-8-Bromo Cyclic Adenosine Monophosphate,
pubmed-meshheading:8953039-Animals,
pubmed-meshheading:8953039-Bacterial Toxins,
pubmed-meshheading:8953039-Body Water,
pubmed-meshheading:8953039-Bone Development,
pubmed-meshheading:8953039-Crosses, Genetic,
pubmed-meshheading:8953039-Cyclic GMP,
pubmed-meshheading:8953039-Cyclic GMP-Dependent Protein Kinases,
pubmed-meshheading:8953039-Diarrhea,
pubmed-meshheading:8953039-Dwarfism,
pubmed-meshheading:8953039-Enterotoxins,
pubmed-meshheading:8953039-Female,
pubmed-meshheading:8953039-Gene Deletion,
pubmed-meshheading:8953039-Growth Plate,
pubmed-meshheading:8953039-Intestinal Mucosa,
pubmed-meshheading:8953039-Male,
pubmed-meshheading:8953039-Mice,
pubmed-meshheading:8953039-Mice, Inbred C57BL,
pubmed-meshheading:8953039-Osteogenesis,
pubmed-meshheading:8953039-Signal Transduction
|
|
pubmed:year |
1996
|
|
pubmed:articleTitle |
Intestinal secretory defects and dwarfism in mice lacking cGMP-dependent protein kinase II.
|
|
pubmed:affiliation |
Institut f-ur Pharmakologie und Toxikologie, Technische Universität München, Biedersteiner Strasse 29, D-80802 M-unchen, Germany. pfeifer@ipt.med.tu-muenchen.de
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
