Linked Life Data

8952962

Source:http://linkedlifedata.com/resource/pubmed/id/8952962

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1997-1-8
pubmed:abstractText
Lack of expression of a cell surface protein can occur by means of transcriptional and/or post-transcriptional mechanisms. Expression of the CD8A gene has been shown to be regulated by post-transcriptional mechanisms when 1) CD4(-)CD8(lo) thymocytes are blocked from differentiating into CD4(+)CD8(+) cells by TCR crosslinking and 2) upon activation of mature CD8(+) T cells. We demonstrate in this paper that there is also post-transcriptional regulation of CD8A expression in a CD4(+)CD8(-) T-cell line Jurkat. On the basis of northern blotting, mRNA for CD8A was not seen to be present in the Jurkat cells, but the gene was observed to be transcriptionally active in nuclear run-on analysis. In addition, we provide evidence that post-transcriptional mechanisms also contribute to the regulation of CD8A expression in mature CD4(+)CD8(-) T cells, challenging the assumption that the regulation is due solely to transcriptional mechanisms.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0093-7711
pubmed:author
pubmed:issnType
Print
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
130-5
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Post-transcriptional regulation associated with control of human CD8A expression of CD4+ T cells.
pubmed:affiliation
Department of Laboratory Medicine, Yale University, 333 Cedar St., New Haven, Connecticut 06520-8035, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.