Linked Life Data

894913

Source:http://linkedlifedata.com/resource/pubmed/id/894913

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1977-10-14
pubmed:abstractText
Sixteen nephrotized rats and eight controls were submitted to a continuous sterol balance for two weeks. During the whole experiment (two months) the rats were pair-fed a balanced sterol-free diet and their proteinuria regularly measured as a parameter of the nephrotic state. Serum cholesterol and albumin were also measured at the end of the experiment. Liver and carcass (excluding intestine and central nervous system) as well as feces were submitted to sterol analysis by gas-liquid chromatography. Sterol losses were corrected for by adding radioactive cholesterol and cholic acid at the beginning of the methodological procedures. The results showed that while fecal sterol excretion was similar in the nephrotic group as compared to controls, a definite increase in serum, carcass, and liver cholesterol was observed in the nephrotic animals, indicating that a real enhancement of synthesis had occurred. The meaning of increased cholesterol hepatic content is discussed, as well as the possible relationship between enhanced protein and cholesterol hepatic synthesis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0085-2538
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
23-7
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1977
pubmed:articleTitle
Origin of hypercholesterolemia in chronic experimental nephrotic syndrome.
pubmed:publicationType
Journal Article