| pubmed-article:8944727 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8944727 | lifeskim:mentions | umls-concept:C0055363 | lld:lifeskim |
| pubmed-article:8944727 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:8944727 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:8944727 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:8944727 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:8944727 | pubmed:issue | 5 Pt 1 | lld:pubmed |
| pubmed-article:8944727 | pubmed:dateCreated | 1997-1-9 | lld:pubmed |
| pubmed-article:8944727 | pubmed:abstractText | Chloride channels supply critical functions in epithelial cells throughout the body. Although function of the volume- and voltage-gated C1C-2 is uncertain, its wide tissue distribution of mRNA suggests C1C-2 has important housekeeping functions. This study's objective was to identify the extent of not only C1C-2 mRNA expression but also protein expression as a measure of the capacity for C1C-2 chloride secretion in epithelial tissues. Using quantitative ribonuclease protection assay, we found that C1C-2 mRNA transcripts were abundant in fetal and postnatal brain, fetal kidney, liver, intestine, and lung. In contrast to brain, C1C-2 mRNA transcripts were downregulated during late gestation in lung, kidney, and intestine. The lung expressed the least C1C-2 mRNA. Immunoblotting demonstrated similar tissue- and gestation-dependent variations in C1C-2 protein expression. To determine if there is a correlation between the sites of C1C-2 protein expression and cystic fibrosis transmembrane conductance regulator (CFTR), another epithelial chloride channel, a polyclonal COOH-terminal C1C-2 antibody and an anti-R domain CFTR anti-body were used. C1C-2 and CFTR were expressed in different sites in lung and kidney. | lld:pubmed |
| pubmed-article:8944727 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8944727 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8944727 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8944727 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8944727 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8944727 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8944727 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8944727 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8944727 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8944727 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:8944727 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:8944727 | pubmed:author | pubmed-author:ChuSS | lld:pubmed |
| pubmed-article:8944727 | pubmed:author | pubmed-author:ZeitlinP LPL | lld:pubmed |
| pubmed-article:8944727 | pubmed:author | pubmed-author:MurrayC BCB | lld:pubmed |
| pubmed-article:8944727 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8944727 | pubmed:volume | 271 | lld:pubmed |
| pubmed-article:8944727 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8944727 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8944727 | pubmed:pagination | L829-37 | lld:pubmed |
| pubmed-article:8944727 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:8944727 | pubmed:meshHeading | pubmed-meshheading:8944727-... | lld:pubmed |
| pubmed-article:8944727 | pubmed:meshHeading | pubmed-meshheading:8944727-... | lld:pubmed |
| pubmed-article:8944727 | pubmed:meshHeading | pubmed-meshheading:8944727-... | lld:pubmed |
| pubmed-article:8944727 | pubmed:meshHeading | pubmed-meshheading:8944727-... | lld:pubmed |
| pubmed-article:8944727 | pubmed:meshHeading | pubmed-meshheading:8944727-... | lld:pubmed |
| pubmed-article:8944727 | pubmed:meshHeading | pubmed-meshheading:8944727-... | lld:pubmed |
| pubmed-article:8944727 | pubmed:meshHeading | pubmed-meshheading:8944727-... | lld:pubmed |
| pubmed-article:8944727 | pubmed:meshHeading | pubmed-meshheading:8944727-... | lld:pubmed |
| pubmed-article:8944727 | pubmed:meshHeading | pubmed-meshheading:8944727-... | lld:pubmed |
| pubmed-article:8944727 | pubmed:meshHeading | pubmed-meshheading:8944727-... | lld:pubmed |
| pubmed-article:8944727 | pubmed:meshHeading | pubmed-meshheading:8944727-... | lld:pubmed |
| pubmed-article:8944727 | pubmed:meshHeading | pubmed-meshheading:8944727-... | lld:pubmed |
| pubmed-article:8944727 | pubmed:meshHeading | pubmed-meshheading:8944727-... | lld:pubmed |
| pubmed-article:8944727 | pubmed:meshHeading | pubmed-meshheading:8944727-... | lld:pubmed |
| pubmed-article:8944727 | pubmed:meshHeading | pubmed-meshheading:8944727-... | lld:pubmed |
| pubmed-article:8944727 | pubmed:meshHeading | pubmed-meshheading:8944727-... | lld:pubmed |
| pubmed-article:8944727 | pubmed:meshHeading | pubmed-meshheading:8944727-... | lld:pubmed |
| pubmed-article:8944727 | pubmed:meshHeading | pubmed-meshheading:8944727-... | lld:pubmed |
| pubmed-article:8944727 | pubmed:meshHeading | pubmed-meshheading:8944727-... | lld:pubmed |
| pubmed-article:8944727 | pubmed:meshHeading | pubmed-meshheading:8944727-... | lld:pubmed |
| pubmed-article:8944727 | pubmed:meshHeading | pubmed-meshheading:8944727-... | lld:pubmed |
| pubmed-article:8944727 | pubmed:meshHeading | pubmed-meshheading:8944727-... | lld:pubmed |
| pubmed-article:8944727 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8944727 | pubmed:articleTitle | Gestational and tissue-specific regulation of C1C-2 chloride channel expression. | lld:pubmed |
| pubmed-article:8944727 | pubmed:affiliation | Eudowood Division of Respiratory Sciences, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA. | lld:pubmed |
| pubmed-article:8944727 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8944727 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8944727 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8944727 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8944727 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8944727 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8944727 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8944727 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8944727 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8944727 | lld:pubmed |
