Linked Life Data

8934573

Source:http://linkedlifedata.com/resource/pubmed/id/8934573

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1997-1-8
pubmed:abstractText
CD4+ CD8+ TCRlo thymocytes are the precursors of CD4+ and CD8+ mature T cells, whose receptors show specific recognition of peptide-MHC class II and MHC class I complexes, respectively. How T cells emerge from the intrathymic differentiation process with selective expression of either CD8 molecule or CD4 molecule coordinated with the MHC class specificity of the TCR has been the subject of intense examination. Many previous studies of this question have been based on the assumption that extinction of CD4 or CD8 expression by the precursor thymocytes was a steady, uninterrupted process. Here we show that this is an incorrect assumption, with CD4 and CD8 expression undergoing an unexpectedly complex series of expression changes involving down-modulation, kinetically asymmetric up-regulation, and then selective loss. Based on these data, we propose a model for the differentiation pathway of alphabeta TCR thymocytes that explains previous, apparently contradictory findings and establishes useful parameters for future studies at the cellular and gene level.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1074-7613
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
461-77
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Unexpectedly complex regulation of CD4/CD8 coreceptor expression supports a revised model for CD4+CD8+ thymocyte differentiation.
pubmed:affiliation
Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892-1892, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't