Linked Life Data

8929580

Source:http://linkedlifedata.com/resource/pubmed/id/8929580

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1997-2-6
pubmed:abstractText
This study determined the relative contributions of systemic (bronchial) and pulmonary blood flow to the intraparenchymal airways >1 mm in diameter by using 15-mu m fluorescent microspheres and fluorescence microscopy in four dogs. Fluorescent microspheres of one color were injected into the inferior vena cava as a pulmonary blood flow marker, and fluorescent microspheres of another color were injected into the left ventricle as a systemic blood flow marker. After the second injection, the animals were killed and the lungs were excised and air dried at total lung capacity. The left lung was sliced into transverse planes and then sectioned into smaller blocks containing airways down to 1 mm in diameter. The blocks were then sectioned using a Vibratome and examined with a fluorescence microscope. Pulmonary and systemic blood flow markers were counted in airway walls, and the diameter of each airway was measured to determine the bronchial tissue volume. After a correction for the number of blood flow markers injected into each circulation, the average ratio of pulmonary to systemic blood flow markers seen in airway walls was 1:37, indicating that 97% of the blood supply to the intraparenchymal airways down to 1 mm in diameter was from the bronchial circulation. Furthermore, on the basis of a weighted least squares regression analysis, systemic (bronchial) blood flow per unit tissue volume increased as airway diameter decreased (P = 0.03).
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
8750-7587
pubmed:author
pubmed:issnType
Print
pubmed:volume
80
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
430-6
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Distribution of pulmonary and bronchial blood supply to airways measured by fluorescent microspheres.
pubmed:affiliation
Division of Pulmonary and Critical Care Medicine, University of Washington, and Veterans Affairs Medical Center, Seattle 98195, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't