Linked Life Data

892947

Source:http://linkedlifedata.com/resource/pubmed/id/892947

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1977-10-14
pubmed:abstractText
Elimination half-life times, plasma concentrations, and minimal cumulation factors are being determined resp. calculated for trimethoprime and sulfametrole (free as well as total amounts)--both combination partners of Lidaprim--in healthy volunteers and in patients with impaired renal function. There is a strong influence of renal function on the cumulation of the metabolized part of the sulfonamide, a weaker one on trimethoprime, and almost none on the free sulfonamide. On account of the sulfonamide metabolite cumulation, a reduction by half of the standard dose of Lidaprim is recommended if the creatinine clearance is below 20-30 ml/min.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0340-0026
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
310-4
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1977
pubmed:articleTitle
Pharmacokinetics of Lidaprim in cases of impaired renal function.
pubmed:publicationType
Journal Article