| pubmed-article:8928793 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8928793 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:8928793 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:8928793 | lifeskim:mentions | umls-concept:C0580247 | lld:lifeskim |
| pubmed-article:8928793 | lifeskim:mentions | umls-concept:C0005528 | lld:lifeskim |
| pubmed-article:8928793 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:8928793 | lifeskim:mentions | umls-concept:C0173022 | lld:lifeskim |
| pubmed-article:8928793 | pubmed:issue | 4 Pt 1 | lld:pubmed |
| pubmed-article:8928793 | pubmed:dateCreated | 1996-11-20 | lld:pubmed |
| pubmed-article:8928793 | pubmed:abstractText | The effect of enteropathogenic Escherichia coli (EPEC) infection on electrophysiology of T84 cell monolayers was examined. After 18 h of infection with EPEC (E2348), transepithelial electrical resistance was decreased (30 +/- 5% of uninfected values) compared with monolayers infected with a nonpathogenic E. coli strain (104 +/- 13%). Resistance of monolayers infected with EPEC mutant strain CVD206, deficient in attaching and effacing lesion formation, was partially reduced (66 +/- 10%). In addition, permeability of EPEC-infected T84 monolayers increased compared with uninfected cells. Associated with these changes was an altered distribution of the tight junction protein, ZO-1. Taken together, these findings suggest that the barrier defect induced by EPEC was at the level of the tight junction. Adenosine 3'5'-cyclic monophosphate-stimulated chloride secretion was also diminished in EPEC-infected cells, whereas Ca2+ -dependent chloride secretion was not different from uninfected cells. These findings indicate that EPEC infection alters intestinal epithelial barrier and transport functions. Furthermore, these results provide a possible mechanism for EPEC-induced diarrheal disease. | lld:pubmed |
| pubmed-article:8928793 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8928793 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8928793 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8928793 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8928793 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:8928793 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:8928793 | pubmed:author | pubmed-author:ShermanP MPM | lld:pubmed |
| pubmed-article:8928793 | pubmed:author | pubmed-author:McKayD MDM | lld:pubmed |
| pubmed-article:8928793 | pubmed:author | pubmed-author:PerdueM HMH | lld:pubmed |
| pubmed-article:8928793 | pubmed:author | pubmed-author:PhilpottD JDJ | lld:pubmed |
| pubmed-article:8928793 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8928793 | pubmed:volume | 270 | lld:pubmed |
| pubmed-article:8928793 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8928793 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8928793 | pubmed:pagination | G634-45 | lld:pubmed |
| pubmed-article:8928793 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:8928793 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8928793 | pubmed:articleTitle | Infection of T84 cells with enteropathogenic Escherichia coli alters barrier and transport functions. | lld:pubmed |
| pubmed-article:8928793 | pubmed:affiliation | Division of Gastroenterology, Hospital for Sick Children, Toronto, Ontario, Canada. | lld:pubmed |
| pubmed-article:8928793 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8928793 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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