Linked Life Data

8926624

Source:http://linkedlifedata.com/resource/pubmed/id/8926624

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1996-11-27
pubmed:abstractText
Oligodendrocytes are responsible for myelination of axons within the central nervous system and are lost in the lesions of multiple sclerosis. The question of whether mature oligodendrocytes are capable of division, and hence of giving rise to new myelinating cells, remains controversial. We have studied the response in vitro of rat oligodendrocytes to growth factors. Unlike their progenitors which divided vigorously in response to growth factor stimulation, mature oligodendrocytes showed no mitotic response to a number of individual growth factors. However, when exposed to basic fibroblast growth factor (bFGF), mature oligodendrocytes expressed the immediate response gene c-fos and the cell cycle-associated protein proliferating cell nuclear antigen, but failed to divide and ultimately underwent cell death by apoptosis. These findings are consistent with the emerging view that mitosis and apoptosis are closely linked phenomena.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0360-4012
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-11
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Growth factor stimulation triggers apoptotic cell death in mature oligodendrocytes.
pubmed:affiliation
University of Cambridge Neurology Unit, Addenbrooke's Hospital, England.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't