Linked Life Data

8922233

Source:http://linkedlifedata.com/resource/pubmed/id/8922233

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1997-3-4
pubmed:abstractText
The efficacy of NRC as a substitute for blood transfusion for treatment of acute, massive hemorrhage was evaluated in this study. Fourteen beagles, anesthetized with a mixture of 50% nitrous oxide, 0.97% sevoflurane and oxygen and ventilated by a respirator, were hemodiluted by withdrawal of 12 ml/kg of blood and infusion of isovolemic HES (hemodilution: HD) four times every 10 min. Then the animals were divided into two groups; an HES group, in which the same HDs were continued and an NRC group, in which the HDs were done with NRC. The hematocrit value decreased to 11% in the HES group after eight HDs and to 13% in the NRC group, which had a 3.9% NRCcrit value during the same period. In the NRC group, Cao2 decreased to 7.9 ml/min, which was significantly higher than the 5.9 ml/dl of the HES group. Oxygen consumption decreased to 56 ml/min in the HES group, but in the NRC group, it dropped to 74 ml/min, which was significantly higher than that of the HES group. Cardiac output increased to 1.2 times that of the control after eight HDs and arterial mean pressure decreased to approximately 60%. The above data indicated that NRC delivered sufficient oxygen to tissues, substituting for circulating red cells and maintained aerobic metabolism. Therefore, it should be possible to use NRC successfully for the treatment of cute, massive hemorrhage.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1073-1199
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
643-53
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Treatment of massive hemorrhage with liposome encapsulated human hemoglobin (NRC) and hydroxyethyl starch (HES) in beagles.
pubmed:affiliation
Department of Anesthesiology, Kawasaki Medical School, Okayama, Japan.
pubmed:publicationType
Journal Article, Comparative Study