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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2-3
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pubmed:dateCreated |
1996-12-30
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pubmed:abstractText |
Certain cytokines are involved in the generation of natural killer (NK) cells and participate in the regulation of the proto-oncogene bcl-2. We aimed to study the mRNA expression of interleukin (IL)-2, IL-4 and IL-5, the composition of the tumour infiltrating lymphocytes (TIL), and the expression of bcl-2 in 14 benign and malignant human parotid tumours. T IL were predominantly composed of T lymphocytes and NK cells. We found evidence for the homing of T cells, and for generation of NK cells in the vicinity of the tumours. mRNA for IL-2 and IL-12, were identified but IL-4 mRNA was not found. The cytokine profiles and the composition of TIL of the two tumour categories were indistinguishable, suggesting that these host-response variables do not explain the differences in biological behaviour of these particular tumours. The results support a shift towards Th 1 (T helper 1) cells and interferon-gamma production, and that IL-12 also in vivo may play an important role in the regulatory interaction between innate resistance and adaptive immunity in tumour diseases. Most infiltrating lymphocytes showed strong expression of bcl-2; an interesting observation with regard to lymphocytic apoptosis in neoplastic diseases. The immunoreactivity for the bcl-2 protein varied considerably between and within tumours, and almost all benign tumours showed strong bcl-2 positively whereas several of the malignant tumours showed weak or absent staining. The variable expression of bcl-2 protein suggests a different susceptibility of tumour cells to apoptosis. The results also indicate that bcl-2 cannot pla a major role as protective agent in the specific apoptotic pathway induced by NK cells.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0945-6317
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
429
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
149-58
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8917716-Humans,
pubmed-meshheading:8917716-Image Processing, Computer-Assisted,
pubmed-meshheading:8917716-Immunohistochemistry,
pubmed-meshheading:8917716-Interleukin-1,
pubmed-meshheading:8917716-Interleukin-12,
pubmed-meshheading:8917716-Killer Cells, Natural,
pubmed-meshheading:8917716-Lymphocyte Subsets,
pubmed-meshheading:8917716-Polymerase Chain Reaction,
pubmed-meshheading:8917716-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:8917716-RNA, Messenger,
pubmed-meshheading:8917716-Salivary Gland Neoplasms
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pubmed:year |
1996
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pubmed:articleTitle |
Bcl-2 immunoreactivity in salivary gland neoplasms is unrelated to the expression of mRNA for natural killer cell stimulatory cytokines interleukin (IL)-2 and IL-12.
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pubmed:affiliation |
Department of Pathology II, University Hospital, Linköping, Sweden. henrik.hellquist@pat.liu.se
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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