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pubmed-article:8915012pubmed:abstractTextGenome-wide DNA hypermethylation induced by 3'-azido-3'-deoxythymidine (AZT) has been suggested to be involved in the development of AZT resistance. We used a CD4 T-lymphoblastoid CEM line and its AZT-resistant MT500 variant with reduced thymidine kinase activity. Evaluation of total DNA methylation, after AZT treatment, failed to show an increase in the 5-methylcytosine level in both parental and AZT-resistant cells. The effect was instead observed at a more specific gene level, on the three HpaII sites present in exon 1 of the human thymidine kinase gene. These results suggest that AZT treatment can induce site-specific hypermethylation, even in the absence of a more general DNA hypermethylating effect.lld:pubmed
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pubmed-article:8915012pubmed:pagination323-6lld:pubmed
pubmed-article:8915012pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:8915012pubmed:year1996lld:pubmed
pubmed-article:8915012pubmed:articleTitleAZT-induced hypermethylation of human thymidine kinase gene in the absence of total DNA hypermethylation.lld:pubmed
pubmed-article:8915012pubmed:affiliationDepartment of Human Biopathology, University of Rome La Sapienza, Italy.lld:pubmed
pubmed-article:8915012pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:8915012pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed