8913762

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0028910, umls-concept:C0205171
pubmed:issue	3
pubmed:dateCreated	1997-3-6
pubmed:abstractText	We propose a fundamental new definition of single ascertainment, namely, that single ascertainment is any ascertainment scheme in which P[pedigree is ascertained/true structure of pedigree] alpha p(theta), where p(theta) is some function of genetic parameters theta but is not a function of pedigree structure. Stated in words: Under single ascertainment, all pedigrees have equal (or proportional with respect to genetic parameters) probabilities of being ascertained, independent of pedigree size or structure. This new definition of single ascertainment allows us to show several results: (1) The correct likelihood consists of the probability of the data conditioned on the observed pedigree, divided by the function p(theta), whether sampling is "proband-independent" or "proband-dependent." (2) More-familiar definitions of single ascertainment all represent special cases of our definition. (3) When p(theta) represents the prevalence of the trait being studied, our definition corresponds to "classical" single ascertainment, i.e., ascertainment through a single "proband." However, the concept of p(theta) can also be generalized to represent the population frequency of configurations of affected relatives (such as affected sib pairs); we call this "generalized single ascertainment."
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/DK-31813, http://linkedlifedata.com/resource/pubmed/grant/MH-28274, http://linkedlifedata.com/resource/pubmed/grant/MH-48858
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/8913762-13626932, http://linkedlifedata.com/resource/pubmed/commentcorrection/8913762-1881876, http://linkedlifedata.com/resource/pubmed/commentcorrection/8913762-3061868, http://linkedlifedata.com/resource/pubmed/commentcorrection/8913762-334399, http://linkedlifedata.com/resource/pubmed/commentcorrection/8913762-3442406, http://linkedlifedata.com/resource/pubmed/commentcorrection/8913762-373427, http://linkedlifedata.com/resource/pubmed/commentcorrection/8913762-3766539, http://linkedlifedata.com/resource/pubmed/commentcorrection/8913762-475336, http://linkedlifedata.com/resource/pubmed/commentcorrection/8913762-523478, http://linkedlifedata.com/resource/pubmed/commentcorrection/8913762-7825570, http://linkedlifedata.com/resource/pubmed/commentcorrection/8913762-7825595, http://linkedlifedata.com/resource/pubmed/commentcorrection/8913762-8651268, http://linkedlifedata.com/resource/pubmed/commentcorrection/8913762-911972
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0374636
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Nov
pubmed:issn	0016-6731
pubmed:author	pubmed-author:HodgeS ESE, pubmed-author:VielandV JVJ
pubmed:issnType	Print
pubmed:volume	144
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	1215-23
pubmed:dateRevised	2009-11-18
pubmed:meshHeading	pubmed-meshheading:8913762-Mathematical Computing, pubmed-meshheading:8913762-Models, Genetic
pubmed:year	1996
pubmed:articleTitle	The essence of single ascertainment.
pubmed:affiliation	Department of Psychiatry, New York State Psychiatric Institute, New York 10032, USA. hodge@child.cpmc.columbia.edu
pubmed:publicationType	Journal Article, Research Support, U.S. Gov't, P.H.S.