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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5291
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pubmed:dateCreated |
1996-12-13
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pubmed:databankReference |
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pubmed:abstractText |
The Caenorhabditis elegans dauer larva is specialized for dispersal without growth and is formed under conditions of overcrowding and limited food. The daf-7 gene, required for transducing environmental cues that support continuous development with plentiful food, encodes a transforming growth factor-beta (TGF-beta) superfamily member. A daf-7 reporter construct is expressed in the ASI chemosensory neurons. Dauer-inducing pheromone inhibits daf-7 expression and promotes dauer formation, whereas food reactivates daf-7 expression and promotes recovery from the dauer state. When the food/pheromone ratio is high, the level of daf-7 mRNA peaks during the L1 larval stage, when commitment to non-dauer development is made.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
22
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pubmed:volume |
274
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1389-91
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:8910282-Amino Acid Sequence,
pubmed-meshheading:8910282-Animals,
pubmed-meshheading:8910282-Animals, Genetically Modified,
pubmed-meshheading:8910282-Caenorhabditis elegans,
pubmed-meshheading:8910282-Caenorhabditis elegans Proteins,
pubmed-meshheading:8910282-Genes, Helminth,
pubmed-meshheading:8910282-Genes, Reporter,
pubmed-meshheading:8910282-Green Fluorescent Proteins,
pubmed-meshheading:8910282-Helminth Proteins,
pubmed-meshheading:8910282-Humans,
pubmed-meshheading:8910282-Larva,
pubmed-meshheading:8910282-Ligands,
pubmed-meshheading:8910282-Luminescent Proteins,
pubmed-meshheading:8910282-Molecular Sequence Data,
pubmed-meshheading:8910282-Mutation,
pubmed-meshheading:8910282-Neurons, Afferent,
pubmed-meshheading:8910282-Phenotype,
pubmed-meshheading:8910282-Pheromones,
pubmed-meshheading:8910282-Temperature,
pubmed-meshheading:8910282-Transforming Growth Factor beta,
pubmed-meshheading:8910282-Transgenes
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pubmed:year |
1996
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pubmed:articleTitle |
Control of C. elegans larval development by neuronal expression of a TGF-beta homolog.
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pubmed:affiliation |
Molecular Biology Program and Division of Biological Sciences, 311 Tucker Hall, University of Missouri, Columbia, MO 65211, USA. riddle@biosci.mbp.missouri.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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