Linked Life Data

8899105

Source:http://linkedlifedata.com/resource/pubmed/id/8899105

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1997-2-12
pubmed:abstractText
Several immunological alterations have been described in inflammatory bowel disease, but their role in the pathogenesis of tissue damage of these disorders is not fully known. Activated immune cells produce proinflammatory and regulatory cytokines able to mediate immune mechanisms underlying intestinal inflammation in both ulcerative colitis and Crohn's disease. Although there is no evidence for an aberrant cytokine secretion in the intestinal mucosa of patients with inflammatory bowel disease, observations seem to indicate that locally released cytokines trigger the preferential differentiation of mucosal lymphocytes into TH1 or TH2 subsets. The unresponsiveness of intestinal mononuclear cells to the inhibiting effects of regulatory cytokines may, also, contribute to this differentiation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0269-2813
pubmed:author
pubmed:issnType
Print
pubmed:volume
10 Suppl 2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
75-9; discussion 80
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Regulatory cytokines in inflammatory bowel disease.
pubmed:affiliation
Dipartimento di Medicina Sperimentale e Clinica, Università di R. Calabria, Catanzaro, Italy.
pubmed:publicationType
Journal Article, Review