Linked Life Data

8889304

Source:http://linkedlifedata.com/resource/pubmed/id/8889304

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1997-1-29
pubmed:abstractText
The aim was to determine the effect of H1- and H2-receptor blockade on histamine-induced changes in nasal airways resistance and lavage protein concentrations. Normal subjects were pretreated with oral cetirizine or ranitidine in a double-blind and randomized manner. Measurements of the concentration of total protein and albumin in nasal lavage fluid together with nasal airway resistance were made before and after challenge. Any effect of treatment was assessed by comparing the areas under the time-response curves. In all nine subjects available for analysis histamine caused an immediate increase in all measurements. Ranitidine reduced the maximum increase in nasal airway resistance, but this effect was significant only in combination with certirizine. The increase in lavage total protein and albumin concentrations was almost completely abolished by cetirizine, whereas ranitidine had less effect. We conclude that the histamine H1-receptor has the greatest effect on changes in nasal vascular permeability induced by topical histamine, whereas the H2-receptor has the greatest effect on nasal obstruction.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0307-7772
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
348-52
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Histamine and the nasal vasculature: the influence of H1 and H2-histamine receptor antagonism.
pubmed:affiliation
University Medicine, Southampton General Hospital, UK.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Randomized Controlled Trial