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rdf:type |
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lifeskim:mentions |
umls-concept:C0001272,
umls-concept:C0006675,
umls-concept:C0007765,
umls-concept:C0027882,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0037473,
umls-concept:C0456962,
umls-concept:C1550548,
umls-concept:C1555714,
umls-concept:C1705654
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pubmed:dateCreated |
1997-2-19
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pubmed:abstractText |
1. Using laser-scanning confocal microscopy, fast Ca2+ transients were recorded in individual not yet myelinated axons of Purkinje neurones in cerebellar slices from young rats. Axonal Ca2+ transients could be detected during a single action potential and had progressively larger amplitudes when the number of action potentials was increased. 2. Under voltage-clamp conditions, axonal Ca2+ transients were as large as those observed in dendrites and in the cell body. Axonal Ca2+ transients were completely blocked by 100 nM of the neurotoxin omega-agatoxin IVA, indicating that they were caused by Ca2+ entry through P-type voltage-gated Ca2+ channels. 3. In conclusion, our results demonstrate action potential-mediated Ca2+ entry through voltage-gated Ca2+ channels in axons of cerebellar Purkinje neurones. Experimental evidence indicates that the resulting transient Ca2+ accumulations regulate the frequency of action potentials travelling along the axon.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8887772-1311418,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8887772-1651493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8887772-1712382,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8887772-2780225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8887772-2847315,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8887772-3676438,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8887772-3681730,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8887772-7479766,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8887772-7679565,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8887772-7716515,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8887772-7826636,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8887772-8394413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8887772-8544123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8887772-8607989,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8887772-8607996,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8887772-8788946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8887772-8821131
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0022-3751
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
495 ( Pt 3)
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
641-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8887772-Action Potentials,
pubmed-meshheading:8887772-Animals,
pubmed-meshheading:8887772-Axons,
pubmed-meshheading:8887772-Calcium,
pubmed-meshheading:8887772-Calcium Channel Blockers,
pubmed-meshheading:8887772-Calcium Channels,
pubmed-meshheading:8887772-Dendrites,
pubmed-meshheading:8887772-Ion Channel Gating,
pubmed-meshheading:8887772-Ion Transport,
pubmed-meshheading:8887772-Microscopy, Confocal,
pubmed-meshheading:8887772-Purkinje Cells,
pubmed-meshheading:8887772-Rats,
pubmed-meshheading:8887772-Rats, Wistar,
pubmed-meshheading:8887772-Signal Transduction,
pubmed-meshheading:8887772-Sodium,
pubmed-meshheading:8887772-Spider Venoms,
pubmed-meshheading:8887772-omega-Agatoxin IVA
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pubmed:year |
1996
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pubmed:articleTitle |
Axonal calcium entry during fast 'sodium' action potentials in rat cerebellar Purkinje neurones.
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pubmed:affiliation |
I. Physiologisches Institute, Universität des Saarlandes, Homburg, Germany.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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