| pubmed-article:8879502 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8879502 | lifeskim:mentions | umls-concept:C0034493 | lld:lifeskim |
| pubmed-article:8879502 | lifeskim:mentions | umls-concept:C0010092 | lld:lifeskim |
| pubmed-article:8879502 | lifeskim:mentions | umls-concept:C0033371 | lld:lifeskim |
| pubmed-article:8879502 | lifeskim:mentions | umls-concept:C0014912 | lld:lifeskim |
| pubmed-article:8879502 | lifeskim:mentions | umls-concept:C0439857 | lld:lifeskim |
| pubmed-article:8879502 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:8879502 | lifeskim:mentions | umls-concept:C0290758 | lld:lifeskim |
| pubmed-article:8879502 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:8879502 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:8879502 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:8879502 | pubmed:dateCreated | 1997-1-30 | lld:pubmed |
| pubmed-article:8879502 | pubmed:abstractText | The recent characterization of the mitochondrial protein, Steroidogenic Acute Regulatory (StAR) protein, as a rate-limiting protein in steroidogenesis prompted us to investigate whether StAR is expressed in the rabbit corpus luteum and whether the expression of StAR is responsive to estradiol-17 beta, the luteotropic hormone in the rabbit. In rabbits treated continuously with exogenous estradiol through Day 13 of pseudopregnancy (n = 9), immunoblot analysis revealed that luteal expression of StAR was stable, ranging from 8.5 to 9.7 U of corrected integrated optical density. Plasma progesterone concentration (mean +/- SEM) remained elevated in these rabbits (14.3 +/- 2.1 ng/ml). In contrast, expression of StAR decreased in corpora lutea of rabbits deprived of estradiol for the last 48 and 72 h of the experiment (4.9 +/- 2.2 and 0.3 +/- 0.2 U, respectively, n = 3 per group), and was associated with a decline in plasma progesterone (0.8 +/- 0.1 and 0.5 +/- 0.3 ng/ml, respectively). Replacement of estradiol after 48 h of estradiol deprivation (n = 3) stimulated the reappearance of StAR (10.3 +/- 2.6 U) and the restoration of plasma progesterone (10.4 +/- 4.9 ng/ml). [35S]Methionine labeling of proteins in rabbit corpora lutea revealed that several isoforms of StAR protein were specifically synthesized in response to estradiol treatment. Collectively, these observations are consistent with a proposed role for StAR in the mediation of the luteotropic effect of estrogen to promote the synthesis of progesterone in the rabbit. | lld:pubmed |
| pubmed-article:8879502 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8879502 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8879502 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8879502 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8879502 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8879502 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8879502 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8879502 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8879502 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8879502 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8879502 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8879502 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8879502 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:8879502 | pubmed:issn | 0006-3363 | lld:pubmed |
| pubmed-article:8879502 | pubmed:author | pubmed-author:KostyoJ LJL | lld:pubmed |
| pubmed-article:8879502 | pubmed:author | pubmed-author:KeyesP LPL | lld:pubmed |
| pubmed-article:8879502 | pubmed:author | pubmed-author:StoccoD MDM | lld:pubmed |
| pubmed-article:8879502 | pubmed:author | pubmed-author:WangX JXJ | lld:pubmed |
| pubmed-article:8879502 | pubmed:author | pubmed-author:TownsonD HDH | lld:pubmed |
| pubmed-article:8879502 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8879502 | pubmed:volume | 55 | lld:pubmed |
| pubmed-article:8879502 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8879502 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8879502 | pubmed:pagination | 868-74 | lld:pubmed |
| pubmed-article:8879502 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:8879502 | pubmed:meshHeading | pubmed-meshheading:8879502-... | lld:pubmed |
| pubmed-article:8879502 | pubmed:meshHeading | pubmed-meshheading:8879502-... | lld:pubmed |
| pubmed-article:8879502 | pubmed:meshHeading | pubmed-meshheading:8879502-... | lld:pubmed |
| pubmed-article:8879502 | pubmed:meshHeading | pubmed-meshheading:8879502-... | lld:pubmed |
| pubmed-article:8879502 | pubmed:meshHeading | pubmed-meshheading:8879502-... | lld:pubmed |
| pubmed-article:8879502 | pubmed:meshHeading | pubmed-meshheading:8879502-... | lld:pubmed |
| pubmed-article:8879502 | pubmed:meshHeading | pubmed-meshheading:8879502-... | lld:pubmed |
| pubmed-article:8879502 | pubmed:meshHeading | pubmed-meshheading:8879502-... | lld:pubmed |
| pubmed-article:8879502 | pubmed:meshHeading | pubmed-meshheading:8879502-... | lld:pubmed |
| pubmed-article:8879502 | pubmed:meshHeading | pubmed-meshheading:8879502-... | lld:pubmed |
| pubmed-article:8879502 | pubmed:meshHeading | pubmed-meshheading:8879502-... | lld:pubmed |
| pubmed-article:8879502 | pubmed:meshHeading | pubmed-meshheading:8879502-... | lld:pubmed |
| pubmed-article:8879502 | pubmed:meshHeading | pubmed-meshheading:8879502-... | lld:pubmed |
| pubmed-article:8879502 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8879502 | pubmed:articleTitle | Expression of the steroidogenic acute regulatory protein in the corpus luteum of the rabbit: dependence upon the luteotropic hormone, estradiol-17 beta. | lld:pubmed |
| pubmed-article:8879502 | pubmed:affiliation | Department of Physiology, University of Michigan Medical School, Ann Arbor 48109-0622, USA. townson@umich.edu | lld:pubmed |
| pubmed-article:8879502 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8879502 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8879502 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8879502 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8879502 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8879502 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8879502 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8879502 | lld:pubmed |
