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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1997-3-11
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pubmed:abstractText |
Controversy exists regarding the nature of the hepatocyte membrane transport system for sulfobromophthalein and other organic anions and its driving forces. Most studies have been performed in the absence of albumin, the plasma sulfobromophthalein binding protein, or using very low albumin concentrations. We have shown that in the latter case uptake kinetics reflect dissociation/diffusion events and not membrane transport. In contrast, without albumin very high sulfobromophthalein concentrations reach the cell surface and may overwhelm a high affinity/low capacity system operating in vivo. The aim of this study was to test the latter hypothesis.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0168-8278
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
178-82
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8878779-Animals,
pubmed-meshheading:8878779-Binding, Competitive,
pubmed-meshheading:8878779-Kinetics,
pubmed-meshheading:8878779-Liver,
pubmed-meshheading:8878779-Male,
pubmed-meshheading:8878779-Osmolar Concentration,
pubmed-meshheading:8878779-Rats,
pubmed-meshheading:8878779-Rats, Sprague-Dawley,
pubmed-meshheading:8878779-Serum Albumin,
pubmed-meshheading:8878779-Sulfobromophthalein
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pubmed:year |
1996
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pubmed:articleTitle |
Hepatocellular sulfobromophthalein uptake at physiologic albumin concentrations: kinetic evidence for a high affinity/low capacity sinusoidal membrane system.
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pubmed:affiliation |
Department of Internal Medicine, University of Udine, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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