Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1996-12-27
pubmed:abstractText
The macrophage resistance gene NRAMP1 regulates priming/activation of macrophages for enhanced TNF alpha, IL 1 beta, and MHC class II expression. Since all of these functions are of potential importance in the induction or maintenance or both of autoimmune disease, samples from the Arthritis and Rheumatism Council's repository of multicase rheumatoid arthritis families were typed for a dinucleotide repeat in the NRAMP1 promoter region and four other 2q34 (TNP1) or 2q35 (IL8R, VIL1, DES) marker genes. Identity by descent (IBD) sib pair analysis using a three locus haplotype NRAMP1-IL8RB-VIL1, or NRAMP1 alone, provided preliminary evidence (maximum lod score = 1.01, p = 0.024) for a gene in this region contributing to suceptibility to rheumatoid arthritis. Candidacy for NRAMP1 as the disease susceptibility gene was supported by a significant bias (p = 0.048) towards transmission of the NRAMP1 promoter region allele 3 in affected offspring.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8863160-1472119, http://linkedlifedata.com/resource/pubmed/commentcorrection/8863160-1541542, http://linkedlifedata.com/resource/pubmed/commentcorrection/8863160-1570492, http://linkedlifedata.com/resource/pubmed/commentcorrection/8863160-1580993, http://linkedlifedata.com/resource/pubmed/commentcorrection/8863160-1689764, http://linkedlifedata.com/resource/pubmed/commentcorrection/8863160-1690327, http://linkedlifedata.com/resource/pubmed/commentcorrection/8863160-1757110, http://linkedlifedata.com/resource/pubmed/commentcorrection/8863160-1789829, http://linkedlifedata.com/resource/pubmed/commentcorrection/8863160-2059076, http://linkedlifedata.com/resource/pubmed/commentcorrection/8863160-2198978, http://linkedlifedata.com/resource/pubmed/commentcorrection/8863160-2258613, http://linkedlifedata.com/resource/pubmed/commentcorrection/8863160-2301392, http://linkedlifedata.com/resource/pubmed/commentcorrection/8863160-2301393, http://linkedlifedata.com/resource/pubmed/commentcorrection/8863160-2301394, http://linkedlifedata.com/resource/pubmed/commentcorrection/8863160-2448638, http://linkedlifedata.com/resource/pubmed/commentcorrection/8863160-2504878, http://linkedlifedata.com/resource/pubmed/commentcorrection/8863160-2676268, http://linkedlifedata.com/resource/pubmed/commentcorrection/8863160-2696047, http://linkedlifedata.com/resource/pubmed/commentcorrection/8863160-3468804, http://linkedlifedata.com/resource/pubmed/commentcorrection/8863160-3865624, http://linkedlifedata.com/resource/pubmed/commentcorrection/8863160-6651220, http://linkedlifedata.com/resource/pubmed/commentcorrection/8863160-6765984, http://linkedlifedata.com/resource/pubmed/commentcorrection/8863160-7485174, http://linkedlifedata.com/resource/pubmed/commentcorrection/8863160-7513015, http://linkedlifedata.com/resource/pubmed/commentcorrection/8863160-7581446, http://linkedlifedata.com/resource/pubmed/commentcorrection/8863160-7698752, http://linkedlifedata.com/resource/pubmed/commentcorrection/8863160-7704030, http://linkedlifedata.com/resource/pubmed/commentcorrection/8863160-7737696, http://linkedlifedata.com/resource/pubmed/commentcorrection/8863160-7848513, http://linkedlifedata.com/resource/pubmed/commentcorrection/8863160-7887437, http://linkedlifedata.com/resource/pubmed/commentcorrection/8863160-7910002, http://linkedlifedata.com/resource/pubmed/commentcorrection/8863160-7921761, http://linkedlifedata.com/resource/pubmed/commentcorrection/8863160-8037216, http://linkedlifedata.com/resource/pubmed/commentcorrection/8863160-8224809, http://linkedlifedata.com/resource/pubmed/commentcorrection/8863160-8430697, http://linkedlifedata.com/resource/pubmed/commentcorrection/8863160-8447318, http://linkedlifedata.com/resource/pubmed/commentcorrection/8863160-8490962, http://linkedlifedata.com/resource/pubmed/commentcorrection/8863160-8508277, http://linkedlifedata.com/resource/pubmed/commentcorrection/8863160-8529098, http://linkedlifedata.com/resource/pubmed/commentcorrection/8863160-8529105
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0022-2593
pubmed:author
pubmed:issnType
Print
pubmed:volume
33
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
672-7
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:8863160-Arthritis, Rheumatoid, pubmed-meshheading:8863160-Carrier Proteins, pubmed-meshheading:8863160-Cation Transport Proteins, pubmed-meshheading:8863160-Chromosomes, Human, Pair 2, pubmed-meshheading:8863160-Dinucleotide Repeats, pubmed-meshheading:8863160-Genes, pubmed-meshheading:8863160-Genetic Linkage, pubmed-meshheading:8863160-Genetic Markers, pubmed-meshheading:8863160-Genetic Predisposition to Disease, pubmed-meshheading:8863160-Haplotypes, pubmed-meshheading:8863160-Humans, pubmed-meshheading:8863160-Likelihood Functions, pubmed-meshheading:8863160-Membrane Proteins, pubmed-meshheading:8863160-Nuclear Family, pubmed-meshheading:8863160-Polymorphism, Genetic, pubmed-meshheading:8863160-Polymorphism, Restriction Fragment Length, pubmed-meshheading:8863160-Promoter Regions, Genetic
pubmed:year
1996
pubmed:articleTitle
Linkage of rheumatoid arthritis to the candidate gene NRAMP1 on 2q35.
pubmed:affiliation
Department of Medicine, University of Cambridge Clinical School, Addenbrooke's Hospital, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't