|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6598
|
|
pubmed:dateCreated |
1996-10-24
|
|
pubmed:abstractText |
A secreted signalling molecule encoded by the Wnt-1 gene is required for development of the central nervous system. In mouse embryos homozygous for a Wnt-1-null allele, the midbrain and anterior hindbrain fail to develop. This corresponds to the region where two transcription factors encoded by the mouse engrailed genes (En-1 and En-2) are normally expressed. Studies of the Drosophila orthologue of Wnt-1, wingless, indicate that Wingless signal is required to maintain engrailed expression in neighbouring cells of the developing epidermis. Here we report that expression of En-1 in the developing midbrain of Wnt-1-null embryos is sufficient to rescue early midbrain and anterior hindbrain development. This suggests that a key role of Wnt-1 signalling is to maintain En expression and that this aspect of the Wnt-1/engrailed interaction has been conserved from flies to mice.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0028-0836
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
26
|
|
pubmed:volume |
383
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
332-4
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
pubmed-meshheading:8848044-Animals,
pubmed-meshheading:8848044-Drosophila,
pubmed-meshheading:8848044-Embryo, Mammalian,
pubmed-meshheading:8848044-Embryo, Nonmammalian,
pubmed-meshheading:8848044-Enhancer Elements, Genetic,
pubmed-meshheading:8848044-Female,
pubmed-meshheading:8848044-Gene Expression Regulation, Developmental,
pubmed-meshheading:8848044-Homeodomain Proteins,
pubmed-meshheading:8848044-Male,
pubmed-meshheading:8848044-Mesencephalon,
pubmed-meshheading:8848044-Mice,
pubmed-meshheading:8848044-Mice, Transgenic,
pubmed-meshheading:8848044-Proto-Oncogene Proteins,
pubmed-meshheading:8848044-Rhombencephalon,
pubmed-meshheading:8848044-Signal Transduction,
pubmed-meshheading:8848044-Wnt Proteins,
pubmed-meshheading:8848044-Wnt1 Protein,
pubmed-meshheading:8848044-Zebrafish Proteins
|
|
pubmed:year |
1996
|
|
pubmed:articleTitle |
Engrailed-1 as a target of the Wnt-1 signalling pathway in vertebrate midbrain development.
|
|
pubmed:affiliation |
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
