Linked Life Data

8847948

Source:http://linkedlifedata.com/resource/pubmed/id/8847948

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
17
pubmed:dateCreated
1996-10-21
pubmed:abstractText
Glutamate receptors play important roles during brain development. We have investigated the effect of chronic maternal alcohol intake on the ontogenic profile of hippocampal glutamate receptor subtypes in their offspring. Binding of 3H-MK-801 to N-methyl-D-aspartate (NMDA) receptor was measured in isolated membranes from the hippocampus of the offspring of pair-fed control and alcohol-fed rats at different times during the postnatal life. Phosphatidylinositol triphosphate (PIP2) hydrolysis was also assayed to provide a measure of the possible effect of ethanol on the metabotropic glutamate receptor (mGluR). In pair-fed control rats, at postnatal day (PND) 3, the 3H-MK-801 binding represents 60% of adult values. Binding then rises to 170% at PND 11, and gradually decreases to adult levels. A transient overshoot in the mGluR-coupled PIP2 hydrolysis was also observed during postnatal development in rat hippocampus. Alcohol-exposed rats showed a similar pattern, but a significant decrease in the specific binding for NMDA receptor was observed on all the postnatal days analyzed. In addition, alcohol exposure significantly decreases the number of specific 3H-MK-801 binding sites, with no change in the affinity of the sites for 3H-MK-801. Moreover, this treatment enhanced the mGluR-activated PIP2 hydrolysis in hippocampus of alcohol-exposed rats. These results may contribute to an understanding of the toxic effects of ethanol on the developing central nervous system (CNS) and help explain the cognitive deficits associated with prenatal alcohol exposure.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0024-3205
pubmed:author
pubmed:issnType
Print
pubmed:day
17
pubmed:volume
56
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1373-83
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Alcohol exposure during brain development reduces 3H-MK-801 binding and enhances metabotropic-glutamate receptor-stimulated phosphoinositide hydrolysis in rat hippocampus.
pubmed:affiliation
Instituto Investigaciones Citológicas (FIB), Valencia, Spain.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't