Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1996-10-21
pubmed:abstractText
To assess the role of HLA genes other than those encoding B27 in predisposing to JAS and AAS, we analyzed the distribution of B*4001, as well as the DRB1, DPB1, and LMP2 alleles, using PCR-based techniques in 63 JAS and 44 AAS patients (all B27 positive). The NBMDR (N = 4724) provided a source of controls matched with the patients for B27 (or other markers when necessary). We found an increase of the B*4001, DRB1*08, and DPB1*0301 alleles, as well as the LMP2 b/b genotype (the latter was most pronounced among patients with acute iridocyclitis), in JAS compared to B27-positive controls. The increase of DRB1*08 and DPB1*0301 was due to an increase of DRB1*08 and DPB1*0301 in combination, whereas the association with B*4001 could be due to linkage disequilibrium with LMP2b. None of these associations were detected in AAS. We conclude that in JAS, in addition to the association to B27, there are also weaker but distinct associations to the DRB1*08, DPB1*0301 alleles and homozygosity for LMP2b.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0198-8859
pubmed:author
pubmed:issnType
Print
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
88-96
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:8847233-Adult, pubmed-meshheading:8847233-Aged, pubmed-meshheading:8847233-Arthritis, Juvenile Rheumatoid, pubmed-meshheading:8847233-Base Sequence, pubmed-meshheading:8847233-Cysteine Endopeptidases, pubmed-meshheading:8847233-Disease Susceptibility, pubmed-meshheading:8847233-Female, pubmed-meshheading:8847233-HLA-B Antigens, pubmed-meshheading:8847233-HLA-DP Antigens, pubmed-meshheading:8847233-HLA-DP beta-Chains, pubmed-meshheading:8847233-HLA-DR Antigens, pubmed-meshheading:8847233-HLA-DRB1 Chains, pubmed-meshheading:8847233-Histocompatibility Testing, pubmed-meshheading:8847233-Homozygote, pubmed-meshheading:8847233-Humans, pubmed-meshheading:8847233-Iridocyclitis, pubmed-meshheading:8847233-Linkage Disequilibrium, pubmed-meshheading:8847233-Male, pubmed-meshheading:8847233-Middle Aged, pubmed-meshheading:8847233-Molecular Sequence Data, pubmed-meshheading:8847233-Prospective Studies, pubmed-meshheading:8847233-Proteins, pubmed-meshheading:8847233-Spondylitis, Ankylosing
pubmed:year
1995
pubmed:articleTitle
Association to HLA-DRB1*08, HLA-DPB1*0301 and homozygosity for an HLA-linked proteasome gene in juvenile ankylosing spondylitis.
pubmed:affiliation
Institute of Transplantation Immunology, National Hospital, Oslo, Norway.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't