Linked Life Data

8847172

Source:http://linkedlifedata.com/resource/pubmed/id/8847172

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1996-10-21
pubmed:abstractText
Immune responses to surface antigens of infective larvae of Ostertagia circumcincta recognized by bile antibodies of sheep immune to challenge were studied in 5-month-old Finn-Dorset male lambs. The sheep were vaccinated subcutaneously with 2 doses of 25 micrograms/kg body weight of surface proteins immunoprecipitated by bile antibodies derived from protected lambs. These antigens were purified from immune complexes by affinity chromatography and then injected with beryllium hydroxide as an adjuvant. The immunized lambs were challenged with 5 x 10(4) L3 and the worm burdens evaluated on day 21 post challenge. These were significantly (P < 0.01) lower in the vaccinated group than in the challenged controls (72% protection). The mucosal and bile IgM, recognizing the L3 surface, showed significantly higher levels in the vaccinated lambs compared to the challenge controls. Mucosal and bile IgA antibody levels against the same antigens were low and no significant differences were observed between vaccinated and control lambs.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0020-7519
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1111-21
pubmed:dateRevised
2010-8-25
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Immune response of lambs to vaccination with Ostertagia circumcincta surface antigens eliciting bile antibody responses.
pubmed:affiliation
Department of Veterinary Parasitology, Warsaw Agricultural University, Poland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't