Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1996-10-23
pubmed:abstractText
Studies of host-parasite relationships in bovine trichomoniasis are presented as a basis for understanding mechanisms of pathogenesis and protection in trichomoniasis in women. The bovine infection is caused by Trichomonas foetus, a trichomonad species closely related to the human pathogen Trichomonas vaginalis. An estrogenized murine model infected with T. vaginalis is useful for the study of virulence factors, but the bovine model has advantages for the study of immunity because T. foetus infection is common in this natural host. In vitro, several virulence factors similar to those of T. vaginalis have been studied, including cysteine proteinases, binding of host cell proteins, and factors involved in attachment to vaginal cells. The biggest advantage of the bovine model, however, is that an efficacious systemic vaccination has been demonstrated to both prevent and treat T. foetus infection. The specificity and isotype of antibodies involved in protection have also been defined. These findings provide encouragement for the development of vaccines against trichomoniasis in humans.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1058-4838
pubmed:author
pubmed:issnType
Print
pubmed:volume
21 Suppl 2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S158-61
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Use of an animal model of trichomoniasis as a basis for understanding this disease in women.
pubmed:affiliation
Division of Infectious Diseases, University of California, San Diego, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Review