Linked Life Data

8844349

Source:http://linkedlifedata.com/resource/pubmed/id/8844349

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1997-1-2
pubmed:abstractText
Prior studies have suggested that hyaluronic acid (HA), a naturally occurring glycosaminoglycan, may accelerate the healing of superficial burn wounds. To objectively assess whether exogenous HA could accelerate the rate of healing and limit scar formation in superficial wounds, 11 patients with burn injuries who were undergoing skin grafting were given two separate skin graft donor sites of similar size and depth (1" x 1" x 0.016"). In a randomized, double-blind fashion, one of these partial-thickness wounds had repeated application with 1.5% HA; 100% glycerin, which served as a control of similar viscosity, was applied to the other wound. On alternating days, photographs were taken and then analyzed with computerized digital planimetry to objectively quantitate the rate of reepithelialization. In contrary to our hypothesis, HA significantly delayed wound healing compared to the glycerin control (time to > 95% reepithelialization: 10.3 +/- 2 days HA vs. 9.1 +/- 1.6 days control; mean +/- SD). Furthermore, no difference in the resultant scar at 6 weeks and at 3 months after wounding was evident. These results demonstrate that HA retards healing of partial thickness wounds in adults.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0273-8481
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
302-4
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:articleTitle
Hyaluronic acid impedes reepithelialization of skin graft donor sites.
pubmed:affiliation
Department of Surgery, Medical College of Virginia Hospitals, Richmond, USA.
pubmed:publicationType
Journal Article, Clinical Trial, Research Support, U.S. Gov't, P.H.S., Randomized Controlled Trial