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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1997-1-30
|
| pubmed:abstractText |
Twenty-three of 34 workers who had worked in the injection molding operation making polyurethane foam parts at an automobile parts manufacturing plant developed respiratory symptoms and/or systemic symptoms over a 2-month period following the full production use of a new diisocyanate paint that contained 1,3-bis(isocyanatomethyl)cyclohexane pre-polymer (BIC)(CAS #75138-76-0, 38661-72-2). At 3 months, all subjects underwent an interview, physical examination, pre- and post-shift pulmonary function tests, and either methacholine challenge test or bronchodilator challenge at an occupational health clinic. The most frequently cited symptoms were dyspnea (65%), cough (61%), chest tightness (57%), chills (57%), wheezing (30%), and myalgias, arthralgias, and nausea (26%). Thirteen subjects had either a positive methacholine challenge test or a positive response to bronchodilator challenge, making the overall prevalence of airway hyperresponsiveness 38%. The overall prevalence of hypersensitivity pneumonitis-like reactions among line operators in the injection molding process was 27%. This disease outbreak suggests that 1,3-bis(isocyanatomethyl)cyclohexane pre-polymer may cause asthma and hypersensitivity pneumonitis-like reactions. The use of BIC was discontinued 6 months after the first workers developed symptoms.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bronchodilator Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclohexanes,
http://linkedlifedata.com/resource/pubmed/chemical/Isocyanates,
http://linkedlifedata.com/resource/pubmed/chemical/Methacholine Chloride,
http://linkedlifedata.com/resource/pubmed/chemical/Polymers
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0271-3586
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
30
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
48-55
|
| pubmed:dateRevised |
2006-2-27
|
| pubmed:meshHeading |
pubmed-meshheading:8837682-Adult,
pubmed-meshheading:8837682-Alveolitis, Extrinsic Allergic,
pubmed-meshheading:8837682-Arthralgia,
pubmed-meshheading:8837682-Asthma,
pubmed-meshheading:8837682-Automobiles,
pubmed-meshheading:8837682-Bronchial Hyperreactivity,
pubmed-meshheading:8837682-Bronchial Provocation Tests,
pubmed-meshheading:8837682-Bronchodilator Agents,
pubmed-meshheading:8837682-Chest Pain,
pubmed-meshheading:8837682-Cough,
pubmed-meshheading:8837682-Cyclohexanes,
pubmed-meshheading:8837682-Dyspnea,
pubmed-meshheading:8837682-Female,
pubmed-meshheading:8837682-Humans,
pubmed-meshheading:8837682-Isocyanates,
pubmed-meshheading:8837682-Male,
pubmed-meshheading:8837682-Methacholine Chloride,
pubmed-meshheading:8837682-Middle Aged,
pubmed-meshheading:8837682-Muscular Diseases,
pubmed-meshheading:8837682-Nausea,
pubmed-meshheading:8837682-Occupational Diseases,
pubmed-meshheading:8837682-Paint,
pubmed-meshheading:8837682-Polymers,
pubmed-meshheading:8837682-Prevalence,
pubmed-meshheading:8837682-Respiratory Sounds,
pubmed-meshheading:8837682-Shivering
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Hypersensitivity pneumonitis-like reaction and occupational asthma associated with 1,3-bis(isocyanatomethyl) cyclohexane pre-polymer.
|
| pubmed:affiliation |
Department of Environmental and Industrial Health, University of Michigan, School of Public Health, Ann Arbor 48109-2029, USA.
|
| pubmed:publicationType |
Journal Article,
Case Reports
|