Linked Life Data

8836552

Source:http://linkedlifedata.com/resource/pubmed/id/8836552

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1997-2-13
pubmed:abstractText
In situ hybridization was employed to study the expression of bcl-2 mRNA and its family members, bax and bcl-x mRNAs, in the developing inner ear. We found that in the cochlear structure, sensory epithelial cells, the spiral ganglion and stria vascularis expressed these mRNAs in postnatal period in a temporally similar manner, but in embryos, neither bax nor bcl-x mRNA were expressed in the sensory epithelium from embryonic day (E) 13 to 19. In contrast to these patterns, bcl-2 mRNA was expressed by E15 to E19, and the expression at E13 was below the lower limit of detection. Non-neuronal tissue (stria vascularis) also expressed these three transcripts during development. These results suggest that bcl-2 family members may be differentially involved in the differentiation of sensory epithelial cells, spiral ganglia, and stria vascularis. In particular, the differential expression patterns in the cochleovestibular neurons suggest that proliferating and differentiating neurons utilize distinct members of the bcl-2 family.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
8
pubmed:volume
726
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
123-8
pubmed:dateRevised
2005-11-17
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Localization of bcl-2, bax, and bcl-x mRNAs in the developing inner ear of the mouse.
pubmed:affiliation
Department of Anatomy and Neuroscience, Osaka University Medical School, Japan.
pubmed:publicationType
Journal Article