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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
11
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pubmed:dateCreated |
1997-1-2
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pubmed:abstractText |
Cytokine production, prevalence of viral isolation, and surface marker expression of peripheral blood mononuclear cells (PBMCs) were analyzed in HIV+ individuals with different patterns of disease progression to establish correlations between these parameters. Thus, mitogen-stimulated in vitro production of interferon gamma (IFN-gamma) and interleukin 2 (IL-2) (type 1 cytokines), and of IL-4 and IL-10 (type 2 cytokines) as well as prevalence of viral isolation were evaluated in 26 HIV+ long-term nonprogressors (LTNPs), in 28 HIV+ patients with progressive HIV infection (PI), and in 24 HIV-seronegative controls (HCs). Surface expression of activation and nonactivation markers was also analyzed in a group of these donors. We report that (1) IL-2 and IFN-gamma production is reduced and IL-4 and IL-10 production is increased in PI patients compared to HCs and LTNPs; (2) prevalence of HIV isolation is lower in LTNPs compared to PI, and the primary viral isolates in LTNPs show a slow/low (S/L) phenotype; and (3) the elevated production of type 2 cytokines is paralleled by an increase in CD57+CD4+CD7- lymphocytes. Thus, whereas a high IL-2, high IFN-gamma/low IL-4, low IL-10 cytokine production pattern is present in HC and in LTNP HIV+, progression of HIV infection is associated with a low IL-2 low IFN-gamma/high IL-4, high IL-10 cytokine profile; increased prevalence of HIV isolation; and an augmented percentage of CD57+CD4+CD7- lymphocytes. These findings further confirm that a dominant type 1 cytokine profile together with reduced prevalence of virus isolation is associated with lack of progression in HIV infection.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-10,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/Phytohemagglutinins
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0889-2229
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1053-61
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:8827221-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:8827221-CD4-Positive T-Lymphocytes,
pubmed-meshheading:8827221-CD8-Positive T-Lymphocytes,
pubmed-meshheading:8827221-Cohort Studies,
pubmed-meshheading:8827221-Cytokines,
pubmed-meshheading:8827221-Flow Cytometry,
pubmed-meshheading:8827221-HIV-1,
pubmed-meshheading:8827221-Humans,
pubmed-meshheading:8827221-Interferon-gamma,
pubmed-meshheading:8827221-Interleukin-10,
pubmed-meshheading:8827221-Interleukin-2,
pubmed-meshheading:8827221-Interleukin-4,
pubmed-meshheading:8827221-Kinetics,
pubmed-meshheading:8827221-Monocytes,
pubmed-meshheading:8827221-Phenotype,
pubmed-meshheading:8827221-Phytohemagglutinins,
pubmed-meshheading:8827221-Survivors,
pubmed-meshheading:8827221-T-Lymphocyte Subsets
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pubmed:year |
1996
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pubmed:articleTitle |
Type 1 cytokine production and low prevalence of viral isolation correlate with long-term nonprogression in HIV infection.
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pubmed:affiliation |
Cattedra di Immunologia, Università degli Studi di Milano, Ospedale L. Sacco, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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