Linked Life Data

8818860

Source:http://linkedlifedata.com/resource/pubmed/id/8818860

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1997-2-24
pubmed:abstractText
The present study examined the influence of two benzimidazole fungicides benomyl and carbendazim (MCB), in dosages of 500 and 1000 mg kg-1 for 5 days, on the capacity of decidual growth in pseudopregnant rats. The aim of the research was to determine whether the antimitotic activity of both chemicals was being mediated by way of hormonal and molecular mechanisms at the uterine level. The results show that both fungicides produced reductions in uterine decidual weight (P < 0.01) and uterine protein content (P < 0.05). However, levels of serum estradiol and progesterone and the binding capacities of cytosol estrogen and progesterone receptors remained essentially unchanged. Subsequently, the antigrowth-antimitotic activity of benomyl and MCB, at 500 and 1000 mg kg-1 dosages, on the decidual uterus is direct, and apparently does not involve steroidal or receptor mechanisms.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0260-437X
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
211-4
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:articleTitle
Effect of benomyl and carbendazim on steroid and molecular mechanisms in uterine decidual growth in rats.
pubmed:affiliation
Department of Biological Sciences, Southern University, Baton Rouge, LA 70813, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't