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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1997-1-15
|
| pubmed:abstractText |
Circulating immune complexes (ICs) were isolated by affinity chromatography and sucrose density gradient fractionation during acute and chronic hepatitis C virus (HCV) infection. Immunochemical and biomolecular studies showed that they basically consist of the virus component, IgG with specific anti-HCV activity and IgM bearing 17.109 epitope (IgM 17.109), an antigenic determinant common to rheumatoid factors (RFs) with WA cross-idiotype (XId). An antigen-specific IC assay was used to demonstrate IgG anti-HCV/IgM 17.109 ICs (IgG-IgM ICs) in five out of the five patients with acute and in 8 out of the 10 patients with chronic hepatitis C who mounted an IgG anti-HCV immune response. They were not detected in patients with no IgG anti-HCV response. IgG-IgM ICs appeared in step with IgG anti-HCV seroconversion and remained detectable for a long period irrespective of clinical outcome, in that they were demonstrated over a 4-year follow-up of patients with chronic hepatitis C. Their presence was unrelated to the severity and progression of liver histology. Despite similar serum levels of IgM 17.109 XId, antigen-specific IgG-IgM ICs were not found in acute and chronic hepatitis B or in acute hepatitis A. Thus, these ICs appear to be uniquely associated with HCV infection, supporting the view that IgM 17.109 XId derive from an antigen-driven response strictly related to the involved antigen. Even although they have no apparent effects on the progression of HCV-related liver disease, their presence may help to explain the immunological abnormalities and extrahepatic disorders observed in HCV infection.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigen-Antibody Complex,
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin M,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Viral
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0014-2972
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
26
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
465-75
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8817160-Acute Disease,
pubmed-meshheading:8817160-Adolescent,
pubmed-meshheading:8817160-Adult,
pubmed-meshheading:8817160-Antigen-Antibody Complex,
pubmed-meshheading:8817160-Biological Markers,
pubmed-meshheading:8817160-Biopsy,
pubmed-meshheading:8817160-Blotting, Western,
pubmed-meshheading:8817160-Child,
pubmed-meshheading:8817160-Female,
pubmed-meshheading:8817160-Follow-Up Studies,
pubmed-meshheading:8817160-Hepatitis, Chronic,
pubmed-meshheading:8817160-Hepatitis A,
pubmed-meshheading:8817160-Hepatitis B,
pubmed-meshheading:8817160-Hepatitis C,
pubmed-meshheading:8817160-Humans,
pubmed-meshheading:8817160-Immunoglobulin G,
pubmed-meshheading:8817160-Immunoglobulin M,
pubmed-meshheading:8817160-Liver,
pubmed-meshheading:8817160-Male,
pubmed-meshheading:8817160-Middle Aged,
pubmed-meshheading:8817160-Polymerase Chain Reaction,
pubmed-meshheading:8817160-RNA, Viral,
pubmed-meshheading:8817160-Time Factors
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Immunochemical and biomolecular studies of circulating immune complexes isolated from patients with acute and chronic hepatitis C virus infection.
|
| pubmed:affiliation |
Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Italy.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|