|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
7
|
|
pubmed:dateCreated |
1996-11-22
|
|
pubmed:abstractText |
The alteration of a glutamic acid (E) to a glycine (G) amino acid residue at position 89 (E89G alteration) in the human immunodeficiency virus type 1 reverse transcriptase confers decreased susceptibility to several nucleoside analog inhibitors. Because the nonnucleoside inhibitor-binding pocket is adjacent to the deoxynucleoside triphosphate substrate-binding site, the impact of the E89G reverse transcriptase has decreased susceptibility to TIBO R82150, nevirapine, and to a lesser extent, delavirdine. Human immunodeficiency viruses bearing the same mutation displayed decreased susceptibility to inhibition by these compounds in a cell culture virus replication assay.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8807067-1279207,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8807067-1317143,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8807067-1377403,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8807067-1699273,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8807067-1716788,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8807067-1722324,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8807067-1722328,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8807067-1727474,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8807067-2434477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8807067-2434858,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8807067-2467383,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8807067-2472634,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8807067-2479983,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8807067-7504909,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8807067-7506027,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8807067-7509000,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8807067-7514855,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8807067-7515055,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8807067-7515182,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8807067-7517553,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8807067-7532321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8807067-7534421,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8807067-7542860,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8807067-7544013,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8807067-7545854,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8807067-7685907,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8807067-7685964,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8807067-7687061,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8807067-7687065,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8807067-7688467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8807067-8133086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8807067-8380641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8807067-8392313,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8807067-8517697
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0066-4804
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
40
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1711-4
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
|
|
pubmed:year |
1996
|
|
pubmed:articleTitle |
The nucleoside analog-resistant E89G mutant of human immunodeficiency virus type 1 reverse transcriptase displays a broader cross-resistance that extends to nonnucleoside inhibitors.
|
|
pubmed:affiliation |
Department of Microbiology & Immunology, Albert Einstein College of Medicine Bronx, New York 10461, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
