Linked Life Data

8805952

Source:http://linkedlifedata.com/resource/pubmed/id/8805952

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1996-12-4
pubmed:abstractText
Chronic toluene inhalation provokes significant deleterious neurological effects in young glue sniffers and exposed workers. We have developed a chronic toluene inhalation model in the cat to address this issue. Neuronal changes using Loyez and acid fuchsinegallocianine stainings were studied at prefrontal cortex, cerebellun and hippocampus. All this structures showed varying degrees of neuronal degeneration to necrosis. Even if injury signs were widespread, the neuronal layers weren't equally affected and there were clear differences in injury severity. In the prefrontal cortex, injured neurons were observed in layers II, III and V/VI extending over several gyri. Lesions were time related, as was more clearly observed in Purkinje cells. In dorsal hippocampus alterations were particulary severe in CA1 and CA3. In ventral hippocampus damaged neurons were scarce and located mainly in CA2. The possible relation of this findings with behavioral changes observed during chronic toluene inhalation are noted.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0003-9829
pubmed:author
pubmed:issnType
Print
pubmed:volume
134
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
217-25
pubmed:dateRevised
2009-10-5
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Neuronal changes induced by chronic toluene exposure in the cat.
pubmed:affiliation
Departamento de Medicina Experimental, Faculatad de Medicina, Universidad de Chile, Santiago, Chile.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't