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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1996-11-7
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pubmed:abstractText |
Voltage-gated K+ channels are modulated by extracellular free unsaturated fatty acids. Both increases and attenuations of K+ channels activities have been observed. We studied the effect of cis-unsaturated fatty acids on Shaker B delta6-46 and the endogenous outward rectifier K+ channels expressed in COS cell line, using the whole cell recording technique. For both K+ channels, exogenously applied unsaturated fatty acids dramatically increased the outward K+ currents. This enhancement was not mediated by cylooxygenase or epoxygenase (P450) enzymes. However, nordihydroguaiaretic acid, a lipoxygenase metabolic pathway blocker, did prevent the arachidonic acid-induced Shaker current enhancement.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0031-6768
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
432
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1091-3
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:8781205-Animals,
pubmed-meshheading:8781205-Arachidonic Acid,
pubmed-meshheading:8781205-COS Cells,
pubmed-meshheading:8781205-Electric Conductivity,
pubmed-meshheading:8781205-Fatty Acids, Unsaturated,
pubmed-meshheading:8781205-Lipoxygenase,
pubmed-meshheading:8781205-Lipoxygenase Inhibitors,
pubmed-meshheading:8781205-Nordihydroguaiaretic Acid,
pubmed-meshheading:8781205-Potassium Channels,
pubmed-meshheading:8781205-Tetraethylammonium,
pubmed-meshheading:8781205-Tetraethylammonium Compounds
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pubmed:year |
1996
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pubmed:articleTitle |
Enhancement of the Shaker B delta6-46 current by fatty acids depends on the activation of the lipoxygenase metabolic pathway.
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pubmed:affiliation |
Departments of Physiology and Neuroscience, Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, MD 21205, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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