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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1977-8-25
|
| pubmed:abstractText |
Methods for the determination of a number of O and/or N-methylated derivatives of norepinephrine were developed. The IP injection of these compounds into rats shows quick absorption and short half-lives in plasma, liver and brain. Most compounds do not cross the Blood-Brain-Barrier (BBB) due to low lipid solubility. However, lipid solubility is not a sole determinant. Compounds which have at least one of the 2 phenolic hydroxyl groups methylated and possess a tertiary amino group do cross the BBB readily.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0034-5164
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
17
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
61-76
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:877406-Animals,
pubmed-meshheading:877406-Blood-Brain Barrier,
pubmed-meshheading:877406-Brain,
pubmed-meshheading:877406-Lipids,
pubmed-meshheading:877406-Liver,
pubmed-meshheading:877406-Male,
pubmed-meshheading:877406-Methylation,
pubmed-meshheading:877406-Norepinephrine,
pubmed-meshheading:877406-Rats,
pubmed-meshheading:877406-Solubility,
pubmed-meshheading:877406-Structure-Activity Relationship,
pubmed-meshheading:877406-Time Factors
|
| pubmed:year |
1977
|
| pubmed:articleTitle |
Penetration of some O-and/or N-methylated norepinephrine derivatives through the rat blood brain barrier.
|
| pubmed:publicationType |
Journal Article
|