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rdf:type |
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lifeskim:mentions |
umls-concept:C0016904,
umls-concept:C0028128,
umls-concept:C0030685,
umls-concept:C0035820,
umls-concept:C0136157,
umls-concept:C0391871,
umls-concept:C0441712,
umls-concept:C0680255,
umls-concept:C1283071,
umls-concept:C1444748,
umls-concept:C1963578
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pubmed:issue |
1-3
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pubmed:dateCreated |
1997-2-4
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pubmed:abstractText |
Role of peroxynitrite in [3H] gamma-aminobutyric acid (GABA) release evoked by N-methyl-D-aspartate (NMDA) and S-nitroso-N-acetyl-penicillamine (SNAP) and mechanisms of [3H]GABA release induced by peroxynitrite in comparison with those induced by NMDA and SNAP were investigated using cerebrocortical neurons. NMDA dose dependently increased [3H]GABA release, which was significantly inhibited by hemoglobin and superoxide scavengers, Cu2+, Zn(2+)-superoxide dismutase and ceruloplasmin. The NMDA-evoked [3H]GABA release was significantly suppressed by GABA transport inhibitors and inhibitors of voltage-dependent L-typed Ca2+ channel. The SNAP-evoked [3H]GABA release was significantly reduced by Ca2+ withdrawal and by GABA transport inhibitors either in the presence or absence of Ca2+. Similar patterns of [3H]GABA release induced by peroxynitrite were observed. These results indicate that peroxynitrite formed by the reaction of NO with superoxide participates, in part, in the release of [3H]GABA induced by NMDA and SNAP.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Ceruloplasmin,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/N-Methylaspartate,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nitrates,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Penicillamine,
http://linkedlifedata.com/resource/pubmed/chemical/S-Nitroso-N-Acetylpenicillamine,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium-Potassium-Exchanging ATPase,
http://linkedlifedata.com/resource/pubmed/chemical/Superoxide Dismutase,
http://linkedlifedata.com/resource/pubmed/chemical/gamma-Aminobutyric Acid,
http://linkedlifedata.com/resource/pubmed/chemical/peroxynitric acid
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0014-2999
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
22
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pubmed:volume |
301
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
179-88
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:8773462-Animals,
pubmed-meshheading:8773462-Cells, Cultured,
pubmed-meshheading:8773462-Ceruloplasmin,
pubmed-meshheading:8773462-Enzyme Inhibitors,
pubmed-meshheading:8773462-Mice,
pubmed-meshheading:8773462-Mice, Inbred Strains,
pubmed-meshheading:8773462-N-Methylaspartate,
pubmed-meshheading:8773462-Nerve Tissue Proteins,
pubmed-meshheading:8773462-Neurons,
pubmed-meshheading:8773462-Nitrates,
pubmed-meshheading:8773462-Nitric Oxide,
pubmed-meshheading:8773462-Penicillamine,
pubmed-meshheading:8773462-S-Nitroso-N-Acetylpenicillamine,
pubmed-meshheading:8773462-Sodium-Potassium-Exchanging ATPase,
pubmed-meshheading:8773462-Superoxide Dismutase,
pubmed-meshheading:8773462-gamma-Aminobutyric Acid
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pubmed:year |
1996
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pubmed:articleTitle |
Role of peroxynitrite in [3H] gamma-aminobutyric acid release evoked by nitric oxide and its mechanism.
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pubmed:affiliation |
Department of Pharmacology, Kyoto Prefectural University of Medicine, Japan. ff
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pubmed:publicationType |
Journal Article
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