| pubmed-article:8769088 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8769088 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:8769088 | lifeskim:mentions | umls-concept:C0022646 | lld:lifeskim |
| pubmed-article:8769088 | lifeskim:mentions | umls-concept:C0022677 | lld:lifeskim |
| pubmed-article:8769088 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:8769088 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:8769088 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:8769088 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:8769088 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:8769088 | lifeskim:mentions | umls-concept:C2003941 | lld:lifeskim |
| pubmed-article:8769088 | lifeskim:mentions | umls-concept:C1948027 | lld:lifeskim |
| pubmed-article:8769088 | lifeskim:mentions | umls-concept:C0728938 | lld:lifeskim |
| pubmed-article:8769088 | lifeskim:mentions | umls-concept:C0205410 | lld:lifeskim |
| pubmed-article:8769088 | lifeskim:mentions | umls-concept:C0205460 | lld:lifeskim |
| pubmed-article:8769088 | lifeskim:mentions | umls-concept:C0218146 | lld:lifeskim |
| pubmed-article:8769088 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8769088 | pubmed:dateCreated | 1996-9-25 | lld:pubmed |
| pubmed-article:8769088 | pubmed:abstractText | Peptide YY (PYY)-preferring receptors are expressed in the renal proximal tubule cell clone Cl.10 isolated from the PKSV-PCT cell line. They mediate PYY-inhibited cAMP production through coupling with pertussis-sensitive Gi proteins. Previous G alpha i RNA antisense experiments demonstrated the exclusive coupling of the PYY receptor to the Gi2 protein. Here we characterized a clone stably expressing G alpha i2 antisense RNA which exhibited only a partial decrease in G alpha i2 content (#60%) as estimated by Western blot. When compared to control Cl.10 cells, this clone, referred to as Cl.10(t), exhibited: (i) an increase in the dissociation constant of PYY receptors (6.42 vs 0.63 nM); (ii) a complete absence of inhibition of [125I]PYY binding by GTP gamma S and GTP; (iii) the failure of PYY to inhibit basal and forskolin-stimulated cAMP levels; (iv) the failure of PYY to stimulate [35S]GTP gamma S binding to membranes. These findings show that partial knockdown of G alpha i2 expression in Cl.10 cells completely abolish the coupling of PYY receptors to biological response. | lld:pubmed |
| pubmed-article:8769088 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8769088 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8769088 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8769088 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8769088 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8769088 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8769088 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8769088 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8769088 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8769088 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8769088 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8769088 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8769088 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8769088 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8769088 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:8769088 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:8769088 | pubmed:author | pubmed-author:LaburtheMM | lld:pubmed |
| pubmed-article:8769088 | pubmed:author | pubmed-author:LorinetA MAM | lld:pubmed |
| pubmed-article:8769088 | pubmed:author | pubmed-author:VoisinTT | lld:pubmed |
| pubmed-article:8769088 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8769088 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:8769088 | pubmed:volume | 225 | lld:pubmed |
| pubmed-article:8769088 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8769088 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8769088 | pubmed:pagination | 16-21 | lld:pubmed |
| pubmed-article:8769088 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:8769088 | pubmed:meshHeading | pubmed-meshheading:8769088-... | lld:pubmed |
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| pubmed-article:8769088 | pubmed:meshHeading | pubmed-meshheading:8769088-... | lld:pubmed |
| pubmed-article:8769088 | pubmed:meshHeading | pubmed-meshheading:8769088-... | lld:pubmed |
| pubmed-article:8769088 | pubmed:meshHeading | pubmed-meshheading:8769088-... | lld:pubmed |
| pubmed-article:8769088 | pubmed:meshHeading | pubmed-meshheading:8769088-... | lld:pubmed |
| pubmed-article:8769088 | pubmed:meshHeading | pubmed-meshheading:8769088-... | lld:pubmed |
| pubmed-article:8769088 | pubmed:meshHeading | pubmed-meshheading:8769088-... | lld:pubmed |
| pubmed-article:8769088 | pubmed:meshHeading | pubmed-meshheading:8769088-... | lld:pubmed |
| pubmed-article:8769088 | pubmed:meshHeading | pubmed-meshheading:8769088-... | lld:pubmed |
| pubmed-article:8769088 | pubmed:meshHeading | pubmed-meshheading:8769088-... | lld:pubmed |
| pubmed-article:8769088 | pubmed:meshHeading | pubmed-meshheading:8769088-... | lld:pubmed |
| pubmed-article:8769088 | pubmed:meshHeading | pubmed-meshheading:8769088-... | lld:pubmed |
| pubmed-article:8769088 | pubmed:meshHeading | pubmed-meshheading:8769088-... | lld:pubmed |
| pubmed-article:8769088 | pubmed:meshHeading | pubmed-meshheading:8769088-... | lld:pubmed |
| pubmed-article:8769088 | pubmed:meshHeading | pubmed-meshheading:8769088-... | lld:pubmed |
| pubmed-article:8769088 | pubmed:meshHeading | pubmed-meshheading:8769088-... | lld:pubmed |
| pubmed-article:8769088 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8769088 | pubmed:articleTitle | Partial knockdown of G alpha i2 protein is sufficient to abolish the coupling of PYY receptors to biological response in renal proximal tubule cells. | lld:pubmed |
| pubmed-article:8769088 | pubmed:affiliation | Unité de Neuroendocrinologie et Biologie Cellulaire Digestives, Institut National de la Santé et de la Recherche Médicale, INSERM U410, Faculté de Médecine X. Bichat, Paris, France. | lld:pubmed |
| pubmed-article:8769088 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8769088 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8769088 | lld:pubmed |
