| pubmed-article:8761445 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8761445 | lifeskim:mentions | umls-concept:C0025936 | lld:lifeskim |
| pubmed-article:8761445 | lifeskim:mentions | umls-concept:C0242692 | lld:lifeskim |
| pubmed-article:8761445 | lifeskim:mentions | umls-concept:C1514559 | lld:lifeskim |
| pubmed-article:8761445 | lifeskim:mentions | umls-concept:C0023816 | lld:lifeskim |
| pubmed-article:8761445 | lifeskim:mentions | umls-concept:C0969677 | lld:lifeskim |
| pubmed-article:8761445 | lifeskim:mentions | umls-concept:C1274040 | lld:lifeskim |
| pubmed-article:8761445 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:8761445 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:8761445 | pubmed:dateCreated | 1996-9-26 | lld:pubmed |
| pubmed-article:8761445 | pubmed:abstractText | Lipoprotein lipase (LPL) has been implicated in the delivery of chylomicron-located alpha-tocopherol (alpha-TocH) to peripheral tissues. To investigate the role of LPL in the cellular uptake of alpha-TocH in peripheral tissue in vivo, three lines of transgenic mice [mouse creatine kinase- (MCK) L, MCK-M and MCK-H] expressing various amounts of human LPL were compared with regard to alpha-TocH levels in plasma, skeletal muscle, cardiac muscle, adipose tissue and brain. Depending on the copy number of the transgene, LPL activity was increased 3- to 27-fold in skeletal muscle and 1.3- to 3.7-fold in cardiac muscle. The intracellular levels of alpha-TocH in skeletal muscle were significantly increased in MCK-M and MCK-H animals and correlated highly with the tissue-specific LPL activity (r = 0.998). The highest levels were observed in MCK-H (21.4 nmol/g) followed by MCK-M (13.3 nmol/g) and MCK-L (8.2 nmol/g) animals when compared with control mice (7.3 nmol/g). Excellent correlation was also observed between intracellular alpha-TocH and non-esterified fatty acid (NEFA) levels (r = 0.998). Although LPL activities in cardiac muscle were also increased in the transgenic mouse lines, alpha-TocH concentrations in the heart remained unchanged. Similarly, alpha-TocH levels in plasma, adipose tissue and brain were unaffected by the tissue specific over-expression of LPL in muscle. The transgenic model presented in this report provides evidence that the uptake of alpha-TocH in muscle is directly dependent on the level of LPL expression in vivo. Increased intracellular alpha-TocH concentrations with increased triglyceride lipolysis and NEFA uptake might protect the myocyte from oxidative damage during increased beta-oxidation. | lld:pubmed |
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| pubmed-article:8761445 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8761445 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8761445 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8761445 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8761445 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:8761445 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:8761445 | pubmed:author | pubmed-author:KostnerG MGM | lld:pubmed |
| pubmed-article:8761445 | pubmed:author | pubmed-author:SattlerWW | lld:pubmed |
| pubmed-article:8761445 | pubmed:author | pubmed-author:RadnerHH | lld:pubmed |
| pubmed-article:8761445 | pubmed:author | pubmed-author:ZechnerRR | lld:pubmed |
| pubmed-article:8761445 | pubmed:author | pubmed-author:Levak-FrankSS | lld:pubmed |
| pubmed-article:8761445 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8761445 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:8761445 | pubmed:volume | 318 ( Pt 1) | lld:pubmed |
| pubmed-article:8761445 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8761445 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8761445 | pubmed:pagination | 15-9 | lld:pubmed |
| pubmed-article:8761445 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8761445 | pubmed:meshHeading | pubmed-meshheading:8761445-... | lld:pubmed |
| pubmed-article:8761445 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8761445 | pubmed:articleTitle | Muscle-specific overexpression of lipoprotein lipase in transgenic mice results in increased alpha-tocopherol levels in skeletal muscle. | lld:pubmed |
| pubmed-article:8761445 | pubmed:affiliation | Department of Medical Biochemistry, University of Graz, Austria. | lld:pubmed |
| pubmed-article:8761445 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8761445 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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