Linked Life Data

8759935

Source:http://linkedlifedata.com/resource/pubmed/id/8759935

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1996-12-5
pubmed:abstractText
Binding of fibrinogen to receptors on the surfaces of activated platelets triggers movement of the ligand-bound receptors. In this study this process was followed by using native and colloidal gold-labeled fibrinogen. Both labeled and unlabeled proteins on platelet surfaces could be visualized by low-voltage, high-resolution scanning electron microscopy. Fibrinogen and gold-conjugated fibrinogen were observed to bind to platelet surfaces and to trigger identical patterns of receptor-ligand complex redistribution. In addition to previously described long- and short-range translocation patterns, fibrinogen, either unlabeled or conjugated to gold particles, formed small, specific, nonfibrillar aggregates after binding to platelet surface receptors. Similar triggering and movement resulted from binding of gold-conjugated antibody to the fibrinogen receptor, but no subsequent self-association of the antibody-gold was observed.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0022-2143
pubmed:author
pubmed:issnType
Print
pubmed:volume
128
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
39-50
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Self-association of bound fibrinogen on platelet surfaces.
pubmed:affiliation
Department of Animal Health and Biomedical Sciences, University of Wisconsin, Madison 53706, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.