Linked Life Data

8758691

Source:http://linkedlifedata.com/resource/pubmed/id/8758691

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1996-9-17
pubmed:abstractText
The effects of endothelin-1 (ET-1) on the electrophysiological activity of pacemaker cells of rabbit sino-atrial node were examined by using intracellular microelectrode technique. The results obtained were as follows: (1) With superfusion of ET-1 (1-30 nmol/l), the velocity of diastolic depolarization (VDD) of pacemaker cells was significantly decreased in a concentration dependent manner, resulting in a reduced rate of pacemaker firing (RPF). (2) The decreases in RPF and VDD induced by ET-1 could be virtually blocked by pretreatment with ET(A) receptor blocker BQ-123 (20 or 100 micrograms/L). It was strongly suggested that the electrophysiological effects of ET-1 on the pacemaker cells were mediated by the ET(A) receptor. (3) The negative chronotropic action of ET-1 on the pacemaker cells was totally abolished by pretreatment with a kind of KATP channel blocker glibenclamide (10 mumol/L). On the basis of above results, it appears that the binding of ET-1 with ET(A) receptor may induce an activation of KATP channels with resultant increase in K+ current so as to decrease the velocity of diastolic depolarization in the pacemaker cells.
pubmed:language
chi
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0371-0874
pubmed:author
pubmed:issnType
Print
pubmed:volume
48
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
53-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
[Effects of endothelin on the electrical activity of sino-atrial pacemaker cells of rabbit].
pubmed:affiliation
Department of Physiology, Hebei Medical University, Shijiazhuang.
pubmed:publicationType
Journal Article, English Abstract, Research Support, Non-U.S. Gov't