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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
1996-9-26
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pubmed:abstractText |
The aim of this study was to assess the role of gamma interferon (IFN-gamma) in a neonatal mouse model of group B streptococcal (GBS) sepsis. IFN-gamma was produced by spleen cells at 24, 48, and 72 h after GBS challenge. Treatment with anti-IFN-gamma at 6 h before challenge totally abrogated the IFN-gamma response but did not affect survival. Subcutaneous administration of recombinant IFN-gamma (2,500 IU per pup) at 18 h after challenge resulted in increased survival time and reduced blood colony counts at 48 and 72 h. In vitro preincubation of neonatal whole blood with IFN-gamma before the addition of GBS resulted in significant restriction of bacterial growth. These data indicate that administration of recombinant IFN-gamma can partially restore impaired host defenses against GBS in neonatal mice. This cytokine may be useful for the treatment of neonatal infections.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8757817-1500748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8757817-1506688,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8757817-1634804,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8757817-1659339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8757817-1705283,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8757817-1824631,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8757817-1846894,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8757817-1910003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8757817-1984480,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8757817-2112583,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8757817-2120341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8757817-2194267,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8757817-2418303,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8757817-2501217,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8757817-3081575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8757817-3081678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8757817-3275727,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8757817-3520322,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8757817-3782828,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8757817-3783329,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8757817-3917274,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8757817-3918100,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8757817-7622884,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8757817-7743365,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8757817-7914909,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8757817-7920463,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8757817-7927780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8757817-8005664,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8757817-8258693,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8757817-8335919,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8757817-8418044,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8757817-8433017,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8757817-8476573
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
64
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2941-4
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8757817-Animals,
pubmed-meshheading:8757817-Animals, Newborn,
pubmed-meshheading:8757817-Chemotaxis, Leukocyte,
pubmed-meshheading:8757817-Colony Count, Microbial,
pubmed-meshheading:8757817-Disease Models, Animal,
pubmed-meshheading:8757817-Interferon-gamma,
pubmed-meshheading:8757817-Mice,
pubmed-meshheading:8757817-Mice, Inbred BALB C,
pubmed-meshheading:8757817-Neutrophils,
pubmed-meshheading:8757817-Shock, Septic,
pubmed-meshheading:8757817-Streptococcal Infections,
pubmed-meshheading:8757817-Streptococcus agalactiae,
pubmed-meshheading:8757817-Tumor Necrosis Factor-alpha
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pubmed:year |
1996
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pubmed:articleTitle |
Role of gamma interferon in a neonatal mouse model of group B streptococcal disease.
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pubmed:affiliation |
Instituto di Microbiologia, Facoltà di Medicina e Chirugia, Universitadegli Studi di Messina, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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