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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1996-10-10
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pubmed:abstractText |
Platelet activating factor (PAF) receptor mRNA was semi-quantitated in microdissected rat nephron segments by the reverse transcription-polymerase chain reaction (RT-PCR). PCR primers were designed from two alternative splicing isoforms of rat PAF receptor cDNA; a homologue of human leukocyte PAF receptor cDNA (p172) and the other with a unique sequence in the 5'-noncoding region upstream of the splice acceptor site (p18). Only the expression of mRNA corresponding to p172 was detectable, which was most abundant in the glomerulus, followed in order by: proximal convoluted tubule > proximal straight tubule > outer medullary and cortical collecting duct, distal convoluted tubule > thick ascending limb of Henle's loop. These results suggest the potential physiological roles of PAF in the entire renal tubule as well as in the glomerulus.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
14
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pubmed:volume |
225
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
352-7
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:8753768-Alternative Splicing,
pubmed-meshheading:8753768-Animals,
pubmed-meshheading:8753768-Base Sequence,
pubmed-meshheading:8753768-DNA Primers,
pubmed-meshheading:8753768-Female,
pubmed-meshheading:8753768-Molecular Sequence Data,
pubmed-meshheading:8753768-Nephrons,
pubmed-meshheading:8753768-Platelet Activating Factor,
pubmed-meshheading:8753768-Platelet Membrane Glycoproteins,
pubmed-meshheading:8753768-Polymerase Chain Reaction,
pubmed-meshheading:8753768-RNA, Messenger,
pubmed-meshheading:8753768-Rats,
pubmed-meshheading:8753768-Rats, Sprague-Dawley,
pubmed-meshheading:8753768-Receptors, Cell Surface,
pubmed-meshheading:8753768-Receptors, G-Protein-Coupled
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pubmed:year |
1996
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pubmed:articleTitle |
Distribution of platelet activating factor receptor mRNA along the rat nephron segments.
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pubmed:affiliation |
First Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan.
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pubmed:publicationType |
Journal Article
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