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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1996-10-11
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pubmed:abstractText |
The ultrasensitive PSA assay has been recently acknowledged as a useful tool for the monitoring of patients prostatectomized for prostatic cancer. We have evaluated a commercially available ultrasensitive PSA assay (Immulite Third Generation PSA-DPC-Los Angeles CA) in comparison with the routinely used PSA (Immulite PSA-DPC-Los Angeles CA). When evaluated with different approaches, the analytical sensitivity of ultrasensitive PSA ranged between 0.0029 and 0.0038 ng/ml. The biological detection limit was 0.0098 ng/ml. Dilution of samples with low PSA levels showed a good recovery (from 88 to 113%) up to 1:128 dilution factor (final PSA levels ranging from 0.004 to 0.016 ng/ml in different samples). The assay precision was excellent in the low dose range, the highest interassay interadjustment CV among replicates being 5.84% when assaying serum samples with PSA lower than 1.0 ng/ml. Besides its role in the follow-up of prostatectomized patients, the evaluated ultrasensitive PSA could be reliably used for the detection of clinically meaningful PSA variations in the low dose range, and it could therefore be a candidate for the assessment of PSA velocity.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0393-6155
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
229-33
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8750651-Aged,
pubmed-meshheading:8750651-Aged, 80 and over,
pubmed-meshheading:8750651-Humans,
pubmed-meshheading:8750651-Male,
pubmed-meshheading:8750651-Monitoring, Physiologic,
pubmed-meshheading:8750651-Prostate-Specific Antigen,
pubmed-meshheading:8750651-Prostatectomy,
pubmed-meshheading:8750651-Prostatic Neoplasms,
pubmed-meshheading:8750651-Reagent Kits, Diagnostic,
pubmed-meshheading:8750651-Regression Analysis,
pubmed-meshheading:8750651-Reproducibility of Results,
pubmed-meshheading:8750651-Sensitivity and Specificity
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pubmed:articleTitle |
Third-generation PSA: ultrasensitive or ultraprecise assay?
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pubmed:affiliation |
Center for the Study of Biological Markers of Malignancy, National Center for the Application of Biotechnologies in Oncology, Venezia, Italy.
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pubmed:publicationType |
Journal Article,
Comparative Study
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