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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1996-10-9
|
| pubmed:abstractText |
A possible causal association between infective dermatitis and HTLV-I infection was reported in 1990 and confirmed in 1992. We now report familial infective dermatitis (ID) occurring in a 26-year-old mother and her 9-year-old son. The mother was first diagnosed with ID in 1969 at the age of 2 years in the Dermatology Unit at the University Hospital of the West Indies (U.H.W.I.) in Jamaica. The elder of her 2 sons was diagnosed with ID at the age of 3 years, also at U.H.W.I. Both mother and son are HTLV-I-seropositive. A second, younger son, currently age 2 years, is also HTLV-I-seropositive, but without clinical evidence of ID. Major histocompatibility complex (MHC), class II, human leucocyte antigen (HLA) genotyping documented a shared class II haplotype, DRB1*DQB1* (1101-0301), in the mother and her 2 sons. This same haplotype has been described among Japanese patients with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP), and has been associated with a possible pathologically heightened immune response to HTLV-I infection. The presence of this haplotype in these familial ID cases with clinical signs of HAM/TSP may have contributed to their risk for development of HAM/TSP. The unaffected, HTLV-I-seropositive younger son requires close clinical follow-up.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DQ Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DQ beta-Chains,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DQB1 antigen,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DR Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DRB1 Chains
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0148-7299
|
| pubmed:author |
pubmed-author:BlankMM,
pubmed-author:CranstonBB,
pubmed-author:FujiyoshiTT,
pubmed-author:GibbsC JCJ,
pubmed-author:HanchardBB,
pubmed-author:LaGrenadeLL,
pubmed-author:MannaSS,
pubmed-author:MillerWW,
pubmed-author:PattVV,
pubmed-author:Rodgers-JohnsonPP,
pubmed-author:SonodaSS,
pubmed-author:YashikiSS
|
| pubmed:issnType |
Print
|
| pubmed:day |
2
|
| pubmed:volume |
61
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
37-41
|
| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:8741915-Adult,
pubmed-meshheading:8741915-Child,
pubmed-meshheading:8741915-Child, Preschool,
pubmed-meshheading:8741915-Dermatitis,
pubmed-meshheading:8741915-Female,
pubmed-meshheading:8741915-Genotype,
pubmed-meshheading:8741915-HLA-DQ Antigens,
pubmed-meshheading:8741915-HLA-DQ beta-Chains,
pubmed-meshheading:8741915-HLA-DR Antigens,
pubmed-meshheading:8741915-HLA-DRB1 Chains,
pubmed-meshheading:8741915-HTLV-I Infections,
pubmed-meshheading:8741915-Haplotypes,
pubmed-meshheading:8741915-Histocompatibility Testing,
pubmed-meshheading:8741915-Humans,
pubmed-meshheading:8741915-Jamaica,
pubmed-meshheading:8741915-Male,
pubmed-meshheading:8741915-Paraparesis, Tropical Spastic,
pubmed-meshheading:8741915-Pedigree,
pubmed-meshheading:8741915-Predictive Value of Tests,
pubmed-meshheading:8741915-Skin Diseases, Infectious
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
HLA DRB1*DQB1* haplotype in HTLV-I-associated familial infective dermatitis may predict development of HTLV-I-associated myelopathy/tropical spastic paraparesis.
|
| pubmed:affiliation |
Department of Medicine, Child Health, and Pathology, University of the West Indies, Mona, Jamaica.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Case Reports
|