| Subject | Predicate | Object | Context |
|---|---|---|---|
| pubmed-article:8729690 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8729690 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:8729690 | lifeskim:mentions | umls-concept:C0242692 | lld:lifeskim |
| pubmed-article:8729690 | lifeskim:mentions | umls-concept:C0001479 | lld:lifeskim |
| pubmed-article:8729690 | lifeskim:mentions | umls-concept:C0032821 | lld:lifeskim |
| pubmed-article:8729690 | lifeskim:mentions | umls-concept:C0871712 | lld:lifeskim |
| pubmed-article:8729690 | lifeskim:mentions | umls-concept:C0392673 | lld:lifeskim |
| pubmed-article:8729690 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:8729690 | pubmed:dateCreated | 1996-10-23 | lld:pubmed |
| pubmed-article:8729690 | pubmed:abstractText | Skeletal muscle is specialized to lose K+ to the extracellular fluid during potassium deprivation which buffers the fall in plasma K+ concentration. While it remains to be determined whether K+ efflux from muscle is altered during K+ deprivation, active K+ uptake driven by sodium pumps is significantly depressed. The activity of sodium pumps in skeletal muscle does not increase during K+ depletion despite elevated intracellular Na+, a strong stimulus to increase activity in other cells. There is a decrease in the total pool size of sodium pump alpha beta heterodimers during potassium deprivation. The alpha 2 (not the alpha 1) sodium pump isoform is specifically decreased and beta 1 and/or beta 2 decreases in a muscle-fibre-dependent manner. The specific loss of K+ from skeletal muscle is probably a consequence of the fact that the alpha 2 isoform predominates in this tissue. In tissues such as heart, where alpha 2-type pumps are only a minor fraction of the sodium pumps, the activity of the ubiquitous alpha 1 isoform maintains intracellular Na+ and K+ at control levels, despite the fact that alpha 2 levels decrease by 50%. Analysis of the time course of change in alpha 2 mRNA vs. protein during K+ deprivation indicates that there is both a decrease in alpha 2 synthesis and an increase in alpha 2 degradation. The apparent time-lag during potassium deprivation between the early decreases in both surface alpha 2-type sodium pump number (assessed by 3H-ouabain binding) and intracellular K+, and the later decrease in total pool size of alpha 2, suggests the hypothesis that there may be an early internalization of alpha 2 sodium pumps to endosomal pools, followed by a degradation of these internalized pumps, contributing to the decrease in total alpha 2 pool size. The signals mediating this specific response to hypokalemia, and those mediating the restoration of muscle K+ stores remain to be determined. | lld:pubmed |
| pubmed-article:8729690 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8729690 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8729690 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8729690 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8729690 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8729690 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:8729690 | pubmed:issn | 0001-6772 | lld:pubmed |
| pubmed-article:8729690 | pubmed:author | pubmed-author:ThompsonC BCB | lld:pubmed |
| pubmed-article:8729690 | pubmed:author | pubmed-author:McDonoughA... | lld:pubmed |
| pubmed-article:8729690 | pubmed:issnType | lld:pubmed | |
| pubmed-article:8729690 | pubmed:volume | 156 | lld:pubmed |
| pubmed-article:8729690 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8729690 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8729690 | pubmed:pagination | 295-304 | lld:pubmed |
| pubmed-article:8729690 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:8729690 | pubmed:meshHeading | pubmed-meshheading:8729690-... | lld:pubmed |
| pubmed-article:8729690 | pubmed:meshHeading | pubmed-meshheading:8729690-... | lld:pubmed |
| pubmed-article:8729690 | pubmed:meshHeading | pubmed-meshheading:8729690-... | lld:pubmed |
| pubmed-article:8729690 | pubmed:meshHeading | pubmed-meshheading:8729690-... | lld:pubmed |
| pubmed-article:8729690 | pubmed:meshHeading | pubmed-meshheading:8729690-... | lld:pubmed |
| pubmed-article:8729690 | pubmed:meshHeading | pubmed-meshheading:8729690-... | lld:pubmed |
| pubmed-article:8729690 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8729690 | pubmed:articleTitle | Role of skeletal muscle sodium pumps in the adaptation to potassium deprivation. | lld:pubmed |
| pubmed-article:8729690 | pubmed:affiliation | Department of Physiology and Biophysics, University of Southern California School of Medicine, Los Angeles 90033, USA. | lld:pubmed |
| pubmed-article:8729690 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8729690 | pubmed:publicationType | Review | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8729690 | lld:pubmed |